Matches in SemOpenAlex for { <https://semopenalex.org/work/W1974156916> ?p ?o ?g. }
- W1974156916 endingPage "270" @default.
- W1974156916 startingPage "261" @default.
- W1974156916 abstract "Lantibiotics are a unique group within the antimicrobial peptides characterized by the presence of thioether amino acids (lanthionine and methyllanthionine). These peptides are produced by and primarily act on Gram-positive bacteria exerting multiple activities at the cytoplasmic membrane of susceptible strains. Previously, the cell wall precursor lipid II was identified as the molecular target for the prototype lantibiotic nisin. Binding and sequestration of lipid II blocks the incorporation of the central cell wall precursor into the growing peptidoglycan network, thereby inhibiting the formation of a functional cell wall. Additionally, nisin combines this activity with a unique target-mediated pore formation, using lipid II as a docking molecule. The interaction with the pyrophosphate moiety of lipid II is crucial for nisin binding. We show that, besides binding to lipid II, nisin interacts with the lipid intermediates lipid III (undecaprenol-pyrophosphate-N-acetyl-glucosamine) and lipid IV (undecaprenol-pyrophosphate-N-acetyl-glucosamine-N-acetyl-mannosamine) of the wall teichoic acid (WTA) biosynthesis pathway. Binding of nisin to the precursors was observed at a stoichiometry of 2:1. The specific interaction with WTA precursors further promoted target-mediated pore formation in artificial lipid bilayers. Specific interactions with lipid III and lipid IV could also be demonstrated for related type A lantibiotics, for example, gallidermin, containing the conserved lipid-II-binding motif." @default.
- W1974156916 created "2016-06-24" @default.
- W1974156916 creator A5009219718 @default.
- W1974156916 creator A5012831105 @default.
- W1974156916 creator A5028048641 @default.
- W1974156916 creator A5065711340 @default.
- W1974156916 creator A5082939593 @default.
- W1974156916 date "2012-06-01" @default.
- W1974156916 modified "2023-10-02" @default.
- W1974156916 title "Interaction of Type A Lantibiotics with Undecaprenol-Bound Cell Envelope Precursors" @default.
- W1974156916 cites W1507817378 @default.
- W1974156916 cites W1548835217 @default.
- W1974156916 cites W1574575997 @default.
- W1974156916 cites W1597947286 @default.
- W1974156916 cites W1963494339 @default.
- W1974156916 cites W1968125869 @default.
- W1974156916 cites W1971914602 @default.
- W1974156916 cites W1972439422 @default.
- W1974156916 cites W1978241413 @default.
- W1974156916 cites W1979404035 @default.
- W1974156916 cites W1985602021 @default.
- W1974156916 cites W1986299243 @default.
- W1974156916 cites W1991308374 @default.
- W1974156916 cites W1991486518 @default.
- W1974156916 cites W1994520308 @default.
- W1974156916 cites W2000129184 @default.
- W1974156916 cites W2000693118 @default.
- W1974156916 cites W2007726705 @default.
- W1974156916 cites W2028940006 @default.
- W1974156916 cites W2029552800 @default.
- W1974156916 cites W2045543226 @default.
- W1974156916 cites W2073097129 @default.
- W1974156916 cites W2079222412 @default.
- W1974156916 cites W2079372854 @default.
- W1974156916 cites W2091367128 @default.
- W1974156916 cites W2119569975 @default.
- W1974156916 cites W2121552999 @default.
- W1974156916 cites W2131709544 @default.
- W1974156916 cites W2132281308 @default.
- W1974156916 cites W2136857987 @default.
- W1974156916 cites W2137489399 @default.
- W1974156916 cites W2146325980 @default.
- W1974156916 cites W2148851922 @default.
- W1974156916 cites W2150152340 @default.
- W1974156916 cites W2156133722 @default.
- W1974156916 cites W2161167549 @default.
- W1974156916 cites W2162708161 @default.
- W1974156916 cites W2163834922 @default.
- W1974156916 cites W2172156581 @default.
- W1974156916 cites W2177308390 @default.
- W1974156916 doi "https://doi.org/10.1089/mdr.2011.0242" @default.
- W1974156916 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22432708" @default.
- W1974156916 hasPublicationYear "2012" @default.
- W1974156916 type Work @default.
- W1974156916 sameAs 1974156916 @default.
- W1974156916 citedByCount "56" @default.
- W1974156916 countsByYear W19741569162012 @default.
- W1974156916 countsByYear W19741569162013 @default.
- W1974156916 countsByYear W19741569162014 @default.
- W1974156916 countsByYear W19741569162015 @default.
- W1974156916 countsByYear W19741569162016 @default.
- W1974156916 countsByYear W19741569162017 @default.
- W1974156916 countsByYear W19741569162018 @default.
- W1974156916 countsByYear W19741569162019 @default.
- W1974156916 countsByYear W19741569162020 @default.
- W1974156916 countsByYear W19741569162021 @default.
- W1974156916 countsByYear W19741569162022 @default.
- W1974156916 countsByYear W19741569162023 @default.
- W1974156916 crossrefType "journal-article" @default.
- W1974156916 hasAuthorship W1974156916A5009219718 @default.
- W1974156916 hasAuthorship W1974156916A5012831105 @default.
- W1974156916 hasAuthorship W1974156916A5028048641 @default.
- W1974156916 hasAuthorship W1974156916A5065711340 @default.
- W1974156916 hasAuthorship W1974156916A5082939593 @default.
- W1974156916 hasConcept C104317684 @default.
- W1974156916 hasConcept C125235067 @default.
- W1974156916 hasConcept C132141352 @default.
- W1974156916 hasConcept C144464004 @default.
- W1974156916 hasConcept C178790620 @default.
- W1974156916 hasConcept C181199279 @default.
- W1974156916 hasConcept C185592680 @default.
- W1974156916 hasConcept C19655278 @default.
- W1974156916 hasConcept C2776043855 @default.
- W1974156916 hasConcept C2776634448 @default.
- W1974156916 hasConcept C2778095248 @default.
- W1974156916 hasConcept C2778253522 @default.
- W1974156916 hasConcept C2778457984 @default.
- W1974156916 hasConcept C2780183148 @default.
- W1974156916 hasConcept C39944091 @default.
- W1974156916 hasConcept C41625074 @default.
- W1974156916 hasConcept C46371251 @default.
- W1974156916 hasConcept C4937899 @default.
- W1974156916 hasConcept C515207424 @default.
- W1974156916 hasConcept C523546767 @default.
- W1974156916 hasConcept C54355233 @default.
- W1974156916 hasConcept C547475151 @default.
- W1974156916 hasConcept C55493867 @default.
- W1974156916 hasConcept C86803240 @default.