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- W1974161847 abstract "We report a flow-injection biosensor system with a capacitive transducer for assay and quality control of human immunoglobulin G (hIgG). The sensing platform is based on self-assembled monolayers (SAMs) of carboxylic acid terminated alkyl-thiols with covalently attached concanavalin A. The electrochemical characteristics of the sensor surface were assessed by cyclic voltammetry using a permeable redox couple (potassium ferricyanide). The developed biosensor proved capable of performing a sensitive label-free assay of hIgG with a detection limit of 1.0 µg mL−1. The capacitance response depended linearly on hIgG concentration over the range from 5.0 to 100 µg mL−1, in a logarithmic plot. Typical measurements were performed in 15 min and up to 18 successive assays were achieved without significant loss of sensitivity using a single electrode. In addition, the biosensor can detect hIgG aggregates with concentrations as low as 0.01% of the total hIgG content (5.0 µg mL−1). Hence, it represents a potential post-size-exclusion chromatography–UV (post-SEC–UV) binding assay for in-process quality control of hIgG, which cannot be detected by SEC–UV singly at concentrations below 0.3% of the total hIgG content. Biotechnol. Bioeng. 2009; 104: 312–320 © 2009 Wiley Periodicals, Inc." @default.
- W1974161847 created "2016-06-24" @default.
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- W1974161847 date "2009-10-01" @default.
- W1974161847 modified "2023-09-27" @default.
- W1974161847 title "A multipurpose capacitive biosensor for assay and quality control of human immunoglobulin G" @default.
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- W1974161847 doi "https://doi.org/10.1002/bit.22395" @default.
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