FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1974175020> ?p ?o ?g. }

• W1974175020 endingPage "5415" @default.
• W1974175020 startingPage "5404" @default.
• W1974175020 abstract "The human bcl-2 gene contains a GC-rich region upstream of the P1 promoter that has been shown to be critically involved in the regulation of bcl-2 gene expression. We have demonstrated that the guanine-rich strand of the DNA in this region can form any one of three distinct intramolecular G-quadruplex structures. Mutation and deletion analysis permitted isolation and identification of three overlapping DNA sequences within this element that formed the three individual G-quadruplexes. Each of these was characterized using nondenaturing gel analysis, DMS footprinting, and circular dichroism. The central G-quadruplex, which is the most stable, forms a mixed parallel/antiparallel structure consisting of three tetrads connected by loops of one, seven, and three bases. Three different G-quadruplex-interactive agents were found to further stabilize these structures, with individual selectivity toward one or more of these G-quadruplexes. Collectively, these results suggest that the multiple G-quadruplexes identified in the promoter region of the bcl-2 gene are likely to play a similar role to the G-quadruplexes in the c-myc promoter in that their formation could serve to modulate gene transcription. Last, we demonstrate that the complexity of the G-quadruplexes in the bcl-2 promoter extends beyond the ability to form any one of three separate G-quadruplexes to each having the capacity to form either three or six different loop isomers. These results are discussed in relation to the biological significance of this G-quadruplex-forming element in modulation of bcl-2 gene expression and the inherent complexity of the system where different G-quadruplexes and loop isomers are possible." @default.
• W1974175020 created "2016-06-24" @default.
• W1974175020 creator A5057930914 @default.
• W1974175020 creator A5061843423 @default.
• W1974175020 creator A5082567112 @default.
• W1974175020 date "2006-03-31" @default.
• W1974175020 modified "2023-09-30" @default.
• W1974175020 title "Deconvoluting the Structural and Drug-Recognition Complexity of the G-Quadruplex-Forming Region Upstream of the <i>bcl-2</i> P1 Promoter" @default.
• W1974175020 cites W1499746632 @default.
• W1974175020 cites W1568678893 @default.
• W1974175020 cites W1874291746 @default.
• W1974175020 cites W1966035396 @default.
• W1974175020 cites W1972071205 @default.
• W1974175020 cites W1972311492 @default.
• W1974175020 cites W1975690779 @default.
• W1974175020 cites W1979160989 @default.
• W1974175020 cites W1990635146 @default.
• W1974175020 cites W1998434054 @default.
• W1974175020 cites W2000977546 @default.
• W1974175020 cites W2003005448 @default.
• W1974175020 cites W2010106126 @default.
• W1974175020 cites W2016446826 @default.
• W1974175020 cites W2021658407 @default.
• W1974175020 cites W2024582476 @default.
• W1974175020 cites W2028753366 @default.
• W1974175020 cites W2028953093 @default.
• W1974175020 cites W2033947577 @default.
• W1974175020 cites W2035667154 @default.
• W1974175020 cites W2038502978 @default.
• W1974175020 cites W2041730421 @default.
• W1974175020 cites W2046127028 @default.
• W1974175020 cites W2052024409 @default.
• W1974175020 cites W2052921338 @default.
• W1974175020 cites W2054452888 @default.
• W1974175020 cites W2060356703 @default.
• W1974175020 cites W2062395030 @default.
• W1974175020 cites W2064632817 @default.
• W1974175020 cites W2069634494 @default.
• W1974175020 cites W2075576299 @default.
• W1974175020 cites W2078458079 @default.
• W1974175020 cites W2085419794 @default.
• W1974175020 cites W2092452241 @default.
• W1974175020 cites W2094644066 @default.
• W1974175020 cites W2155616092 @default.
• W1974175020 cites W2160632934 @default.
• W1974175020 cites W2166976426 @default.
• W1974175020 cites W2275275778 @default.
• W1974175020 doi "https://doi.org/10.1021/ja0563861" @default.
• W1974175020 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2580050" @default.
• W1974175020 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16620112" @default.
• W1974175020 hasPublicationYear "2006" @default.
• W1974175020 type Work @default.
• W1974175020 sameAs 1974175020 @default.
• W1974175020 citedByCount "340" @default.
• W1974175020 countsByYear W19741750202012 @default.
• W1974175020 countsByYear W19741750202013 @default.
• W1974175020 countsByYear W19741750202014 @default.
• W1974175020 countsByYear W19741750202015 @default.
• W1974175020 countsByYear W19741750202016 @default.
• W1974175020 countsByYear W19741750202017 @default.
• W1974175020 countsByYear W19741750202018 @default.
• W1974175020 countsByYear W19741750202019 @default.
• W1974175020 countsByYear W19741750202020 @default.
• W1974175020 countsByYear W19741750202021 @default.
• W1974175020 countsByYear W19741750202022 @default.
• W1974175020 countsByYear W19741750202023 @default.
• W1974175020 crossrefType "journal-article" @default.
• W1974175020 hasAuthorship W1974175020A5057930914 @default.
• W1974175020 hasAuthorship W1974175020A5061843423 @default.
• W1974175020 hasAuthorship W1974175020A5082567112 @default.
• W1974175020 hasBestOaLocation W19741750202 @default.
• W1974175020 hasConcept C101762097 @default.
• W1974175020 hasConcept C104317684 @default.
• W1974175020 hasConcept C115260700 @default.
• W1974175020 hasConcept C121332964 @default.
• W1974175020 hasConcept C133571119 @default.
• W1974175020 hasConcept C138885662 @default.
• W1974175020 hasConcept C142089489 @default.
• W1974175020 hasConcept C150194340 @default.
• W1974175020 hasConcept C153911025 @default.
• W1974175020 hasConcept C179926584 @default.
• W1974175020 hasConcept C185592680 @default.
• W1974175020 hasConcept C22427896 @default.
• W1974175020 hasConcept C2778021871 @default.
• W1974175020 hasConcept C2778301229 @default.
• W1974175020 hasConcept C41895202 @default.
• W1974175020 hasConcept C512185932 @default.
• W1974175020 hasConcept C54355233 @default.
• W1974175020 hasConcept C552990157 @default.
• W1974175020 hasConcept C55493867 @default.
• W1974175020 hasConcept C62520636 @default.
• W1974175020 hasConcept C67705224 @default.
• W1974175020 hasConcept C71240020 @default.
• W1974175020 hasConcept C75079739 @default.
• W1974175020 hasConcept C83762044 @default.
• W1974175020 hasConcept C86339819 @default.
• W1974175020 hasConcept C86803240 @default.
• W1974175020 hasConceptScore W1974175020C101762097 @default.

• next