FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1974182198> ?p ?o ?g. }

• W1974182198 endingPage "223" @default.
• W1974182198 startingPage "215" @default.
• W1974182198 abstract "Cell migration is a fundamental process occurring during embryonic development and tissue morphogenesis. In the nematode Caenorhabditis elegans, morphogenesis of the body-wall musculature involves short-range migrations of 81 embryonic muscle cells from the lateral surface of the embryo towards the dorsal and ventral midlines. This study shows that mutations in ina-1 (alpha-integrin), as well as vab-1 (Eph receptor), and vab-2 (ephrin), display defects in embryonic muscle cell migration. Furthermore, an RNAi-based enhancer screen in an ina-1 weak loss-of-function background identified mnp-1 (matrix non-peptidase homologue-1) as a previously uncharacterized gene required for promoting proper migration of the embryonic muscle cells. mnp-1 encodes a membrane associated metalloproteinase homologue that is predicted to be catalytically inactive. Our data suggest that MNP-1 is expressed in migrating muscle cells and localizes to the plasma membrane with the non-peptidase domain exposed to the extra-cellular environment. Double-mutant analysis between mnp-1(RNAi), ina-1, and vab-1 mutations; as well as tissue specific rescue experiments; indicated that each of these gene products function predominantly independent of each other and from different cell types to affect muscle cell migration. Together these results suggest complex interactions between the adjacent epidermal, neuronal, and muscle cells are required to promote proper muscle cell migration during embryogenesis." @default.
• W1974182198 created "2016-06-24" @default.
• W1974182198 creator A5004096220 @default.
• W1974182198 creator A5028102465 @default.
• W1974182198 date "2008-06-01" @default.
• W1974182198 modified "2023-09-25" @default.
• W1974182198 title "Muscle cell migrations of C. elegans are mediated by the α-integrin INA-1, Eph receptor VAB-1, and a novel peptidase homologue MNP-1" @default.
• W1974182198 cites W1647075334 @default.
• W1974182198 cites W1921244251 @default.
• W1974182198 cites W1944127002 @default.
• W1974182198 cites W1988692408 @default.
• W1974182198 cites W1989952069 @default.
• W1974182198 cites W2000814069 @default.
• W1974182198 cites W2016701198 @default.
• W1974182198 cites W2020063796 @default.
• W1974182198 cites W2030776545 @default.
• W1974182198 cites W2032579724 @default.
• W1974182198 cites W2043481572 @default.
• W1974182198 cites W2051154350 @default.
• W1974182198 cites W2053437284 @default.
• W1974182198 cites W2066630811 @default.
• W1974182198 cites W2067701788 @default.
• W1974182198 cites W2078301833 @default.
• W1974182198 cites W2079902244 @default.
• W1974182198 cites W2101276421 @default.
• W1974182198 cites W2119646657 @default.
• W1974182198 cites W2141348037 @default.
• W1974182198 cites W2142305917 @default.
• W1974182198 cites W2143621104 @default.
• W1974182198 cites W2145294610 @default.
• W1974182198 cites W2145468604 @default.
• W1974182198 cites W2146597600 @default.
• W1974182198 cites W2153160639 @default.
• W1974182198 cites W2154378559 @default.
• W1974182198 cites W2181856146 @default.
• W1974182198 cites W2182641896 @default.
• W1974182198 cites W2335776432 @default.
• W1974182198 cites W4232690806 @default.
• W1974182198 cites W4232731786 @default.
• W1974182198 doi "https://doi.org/10.1016/j.ydbio.2008.02.062" @default.
• W1974182198 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2453148" @default.
• W1974182198 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18452914" @default.
• W1974182198 hasPublicationYear "2008" @default.
• W1974182198 type Work @default.
• W1974182198 sameAs 1974182198 @default.
• W1974182198 citedByCount "16" @default.
• W1974182198 countsByYear W19741821982012 @default.
• W1974182198 countsByYear W19741821982014 @default.
• W1974182198 countsByYear W19741821982015 @default.
• W1974182198 countsByYear W19741821982016 @default.
• W1974182198 countsByYear W19741821982017 @default.
• W1974182198 countsByYear W19741821982023 @default.
• W1974182198 crossrefType "journal-article" @default.
• W1974182198 hasAuthorship W1974182198A5004096220 @default.
• W1974182198 hasAuthorship W1974182198A5028102465 @default.
• W1974182198 hasBestOaLocation W19741821981 @default.
• W1974182198 hasConcept C104317684 @default.
• W1974182198 hasConcept C137738243 @default.
• W1974182198 hasConcept C145103041 @default.
• W1974182198 hasConcept C1491633281 @default.
• W1974182198 hasConcept C166703698 @default.
• W1974182198 hasConcept C170286479 @default.
• W1974182198 hasConcept C195687474 @default.
• W1974182198 hasConcept C2778944004 @default.
• W1974182198 hasConcept C40692019 @default.
• W1974182198 hasConcept C54355233 @default.
• W1974182198 hasConcept C62478195 @default.
• W1974182198 hasConcept C67705224 @default.
• W1974182198 hasConcept C86803240 @default.
• W1974182198 hasConcept C95444343 @default.
• W1974182198 hasConceptScore W1974182198C104317684 @default.
• W1974182198 hasConceptScore W1974182198C137738243 @default.
• W1974182198 hasConceptScore W1974182198C145103041 @default.
• W1974182198 hasConceptScore W1974182198C1491633281 @default.
• W1974182198 hasConceptScore W1974182198C166703698 @default.
• W1974182198 hasConceptScore W1974182198C170286479 @default.
• W1974182198 hasConceptScore W1974182198C195687474 @default.
• W1974182198 hasConceptScore W1974182198C2778944004 @default.
• W1974182198 hasConceptScore W1974182198C40692019 @default.
• W1974182198 hasConceptScore W1974182198C54355233 @default.
• W1974182198 hasConceptScore W1974182198C62478195 @default.
• W1974182198 hasConceptScore W1974182198C67705224 @default.
• W1974182198 hasConceptScore W1974182198C86803240 @default.
• W1974182198 hasConceptScore W1974182198C95444343 @default.
• W1974182198 hasIssue "2" @default.
• W1974182198 hasLocation W19741821981 @default.
• W1974182198 hasLocation W19741821982 @default.
• W1974182198 hasLocation W19741821983 @default.
• W1974182198 hasLocation W19741821984 @default.
• W1974182198 hasOpenAccess W1974182198 @default.
• W1974182198 hasPrimaryLocation W19741821981 @default.
• W1974182198 hasRelatedWork W1969588473 @default.
• W1974182198 hasRelatedWork W1973829952 @default.
• W1974182198 hasRelatedWork W2038492783 @default.
• W1974182198 hasRelatedWork W2046022275 @default.
• W1974182198 hasRelatedWork W2106231435 @default.
• W1974182198 hasRelatedWork W2111634467 @default.
• W1974182198 hasRelatedWork W2125771053 @default.

• next