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- W1974182703 abstract "IVIG binds to abnormally folded proteins, such as oligomeric beta amyloid and alpha synuclein, thought to be involved in AD and LBD pathogenesis. IVIG treatment may be useful in these disorders. In this study, we've evaluated treatment efficacy of intravenous immunoglobulin (IVIG) therapy in Alzheimer's disease (AD) and Lewy body disease (LBD). Nine AD and 4 LBD patients received IVIG therapy for means of 16 (σ=8) and 10 (σ=6) months. Dementia severity (1 MCI, 4 mild, 1 moderate, and 3 moderately severe AD; 1 moderate and 3 moderately severe LBD) was determined using the Functional Assessment Staging Test (FAST). Pre-IVIG monitoring of AD and LBD patients using MCI Screen and FAST tests averaged 21 (σ=12) and 36 (σ=16) months respectively. Cognitive, functional and behavioral testing at baseline and during IVIG therapy consisted of ADAS-Cog, MMSE, MCI Screen, NPI, ADCS-ADL, DAD, FAST, and CGIC tests. Baseline and endpoint CSF Tau and Ab42 levels were obtained when possible. IVIG therapy either stabilized or significantly slowed cognitive and functional decline in most of the AD and LBD patients. Of the AD and LBD patients who discontinued IVIG treatment_primarily due to cost_they declined more rapidly within months after stopping IVIG than while they were on it. CSF studies suggested that IVIG reduced either beta amyloid 1–42 levels, or phosphorylated tau levels, or both. IVIG therapy appears to be an effective treatment for delaying disease progression in patients with AD and LBD. More rigorous clinical trials are needed, particularly in LBD." @default.
- W1974182703 created "2016-06-24" @default.
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- W1974182703 date "2008-07-01" @default.
- W1974182703 modified "2023-09-27" @default.
- W1974182703 title "P2-434: IVIG therapy in Alzheimer's and Lewy body disease" @default.
- W1974182703 doi "https://doi.org/10.1016/j.jalz.2008.05.1513" @default.
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