Matches in SemOpenAlex for { <https://semopenalex.org/work/W1974184531> ?p ?o ?g. }
- W1974184531 endingPage "339" @default.
- W1974184531 startingPage "329" @default.
- W1974184531 abstract "The organophosphates, diisopropyl phosphorofluoridate and soman have a common mechanism of action (inhibition of acetylcholinesterase), but result in very different behavioral responses in the rat. Soman rapidly produced persistent tonic convulsions whereas diisopropyl phosphorofluoridate only infrequently produced transient convulsive-like activity. Soman increased local cerebral glucose use in most of the cortex, striato-pallido-nigral pathway, limbic system and in specific thalamic nuclei whereas diisopropyl phosphorofluoridate increased glucose use in a limited fashion, primarily in the dorsal striato-pallido-nigral pathway. When diazepam blocked soman-induced convulsions, the pattern of glucose use was strikingly similar to that caused by diisopropyl phosphorofluoridate. Soman or diisopropyl phosphorofluoridate depressed local cerebral glucose use in rats pretreated with the antidotal mixture of trimedoxime, atropine and benactyzine (muscarinic antagonists). Also, this antidotal mixture blocked the increased glucose use in the dorsal striato-pallido-nigral system produced by either acetylcholinesterase inhibitor, indicating that muscarinic receptors mediate the excitation of this pathway. Both diisopropyl phosphorofluoridate and soman activate the striato-pallido-nigral pathway but soman also causes spread of activity producing overt motor convulsions. Possible explanations for this difference in response to the organophosphates are differential responses in cholinergic actions within specific brain regions or some non-cholinergic action of soman" @default.
- W1974184531 created "2016-06-24" @default.
- W1974184531 creator A5006117259 @default.
- W1974184531 creator A5014603439 @default.
- W1974184531 creator A5033289006 @default.
- W1974184531 creator A5041943793 @default.
- W1974184531 creator A5062630573 @default.
- W1974184531 creator A5066088098 @default.
- W1974184531 date "1987-01-01" @default.
- W1974184531 modified "2023-09-25" @default.
- W1974184531 title "Cholinergic systems influence local cerebral glucose use in specific anatomical areas: Diisopropyl phosphorofluoridate versus soman" @default.
- W1974184531 cites W1487472841 @default.
- W1974184531 cites W1568239579 @default.
- W1974184531 cites W1819535489 @default.
- W1974184531 cites W1971152807 @default.
- W1974184531 cites W1983493352 @default.
- W1974184531 cites W1988359833 @default.
- W1974184531 cites W1993530169 @default.
- W1974184531 cites W1994280422 @default.
- W1974184531 cites W2002175811 @default.
- W1974184531 cites W2002880606 @default.
- W1974184531 cites W2003289804 @default.
- W1974184531 cites W2013926783 @default.
- W1974184531 cites W2018653374 @default.
- W1974184531 cites W2019808458 @default.
- W1974184531 cites W2023642970 @default.
- W1974184531 cites W2029101828 @default.
- W1974184531 cites W2040391121 @default.
- W1974184531 cites W2050723087 @default.
- W1974184531 cites W2054117641 @default.
- W1974184531 cites W2059788187 @default.
- W1974184531 cites W2072117089 @default.
- W1974184531 cites W2075079489 @default.
- W1974184531 cites W2079794573 @default.
- W1974184531 cites W2081697928 @default.
- W1974184531 cites W2085249008 @default.
- W1974184531 cites W2088280880 @default.
- W1974184531 cites W2089258031 @default.
- W1974184531 cites W2090306035 @default.
- W1974184531 cites W2111410522 @default.
- W1974184531 cites W2163815564 @default.
- W1974184531 cites W2403523770 @default.
- W1974184531 cites W2409970480 @default.
- W1974184531 cites W2471470829 @default.
- W1974184531 cites W2415935956 @default.
- W1974184531 doi "https://doi.org/10.1016/0306-4522(87)90023-6" @default.
- W1974184531 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3561766" @default.
- W1974184531 hasPublicationYear "1987" @default.
- W1974184531 type Work @default.
- W1974184531 sameAs 1974184531 @default.
- W1974184531 citedByCount "20" @default.
- W1974184531 countsByYear W19741845312013 @default.
- W1974184531 countsByYear W19741845312016 @default.
- W1974184531 crossrefType "journal-article" @default.
- W1974184531 hasAuthorship W1974184531A5006117259 @default.
- W1974184531 hasAuthorship W1974184531A5014603439 @default.
- W1974184531 hasAuthorship W1974184531A5033289006 @default.
- W1974184531 hasAuthorship W1974184531A5041943793 @default.
- W1974184531 hasAuthorship W1974184531A5062630573 @default.
- W1974184531 hasAuthorship W1974184531A5066088098 @default.
- W1974184531 hasConcept C126322002 @default.
- W1974184531 hasConcept C134018914 @default.
- W1974184531 hasConcept C15744967 @default.
- W1974184531 hasConcept C169760540 @default.
- W1974184531 hasConcept C170493617 @default.
- W1974184531 hasConcept C181199279 @default.
- W1974184531 hasConcept C185592680 @default.
- W1974184531 hasConcept C22885893 @default.
- W1974184531 hasConcept C2775859210 @default.
- W1974184531 hasConcept C2776873056 @default.
- W1974184531 hasConcept C2778816929 @default.
- W1974184531 hasConcept C2780266723 @default.
- W1974184531 hasConcept C33789571 @default.
- W1974184531 hasConcept C42219234 @default.
- W1974184531 hasConcept C55493867 @default.
- W1974184531 hasConcept C71924100 @default.
- W1974184531 hasConcept C98274493 @default.
- W1974184531 hasConceptScore W1974184531C126322002 @default.
- W1974184531 hasConceptScore W1974184531C134018914 @default.
- W1974184531 hasConceptScore W1974184531C15744967 @default.
- W1974184531 hasConceptScore W1974184531C169760540 @default.
- W1974184531 hasConceptScore W1974184531C170493617 @default.
- W1974184531 hasConceptScore W1974184531C181199279 @default.
- W1974184531 hasConceptScore W1974184531C185592680 @default.
- W1974184531 hasConceptScore W1974184531C22885893 @default.
- W1974184531 hasConceptScore W1974184531C2775859210 @default.
- W1974184531 hasConceptScore W1974184531C2776873056 @default.
- W1974184531 hasConceptScore W1974184531C2778816929 @default.
- W1974184531 hasConceptScore W1974184531C2780266723 @default.
- W1974184531 hasConceptScore W1974184531C33789571 @default.
- W1974184531 hasConceptScore W1974184531C42219234 @default.
- W1974184531 hasConceptScore W1974184531C55493867 @default.
- W1974184531 hasConceptScore W1974184531C71924100 @default.
- W1974184531 hasConceptScore W1974184531C98274493 @default.
- W1974184531 hasIssue "1" @default.
- W1974184531 hasLocation W19741845311 @default.
- W1974184531 hasLocation W19741845312 @default.
- W1974184531 hasOpenAccess W1974184531 @default.