FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1974184735> ?p ?o ?g. }

• W1974184735 endingPage "e105787" @default.
• W1974184735 startingPage "e105787" @default.
• W1974184735 abstract "Lipid accumulation has been shown to accelerate renal injury, and the intracellular accumulation of lipids may be caused by alterations in synthesis as well as lipid uptake and efflux. We have investigated the role of cellular cholesterol transport proteins including adenosine triphosphate binding cassette transporter A1 (ABCA1), G1 (ABCG1) and scavenger receptor class B type I (SR-BI) in diabetic nephropathy.Protein expression and the ability to mediate cholesterol efflux of ABCA1, ABCG1 and SR-BI was determined in human renal mesangial cells and proximal tubular epithelial cells cultured under normal or high glucose conditions. Renal expression of these cholesterol transporters was examined in a murine model of streptozotocin-induced type 1 diabetes.ABCA1, ABCG1 and SR-BI were expressed in both human renal mesangial cells and proximal tubular epithelial cells, and mediated cholesterol efflux to apolipoprotein AI and HDL. In vitro, hyperglycemia reduced the expression and the ability to mediate cholesterol efflux of all three cholesterol transporters (p<0.05). In vivo studies showed that intra-renal accumulation of lipids was increased in diabetic mice, particularly in mice with nephropathy. This was associated with a significant reduction in the expression of ABCA1, ABCG1 and SR-BI in the kidneys. These changes were already seen in diabetic mice without nephropathy and preceded the development of nephropathy. Diabetic mice with nephropathy had the lowest level of these cholesterol transporters.Inducing diabetes with streptozotocin significantly reduced renal expression of ABCA1, ABCG1 and SR-BI. Defects in cholesterol export pathway in renal cells could therefore promote cholesterol accumulation and might contribute to the development of diabetic nephropathy." @default.
• W1974184735 created "2016-06-24" @default.
• W1974184735 creator A5010329388 @default.
• W1974184735 creator A5011859890 @default.
• W1974184735 creator A5013826550 @default.
• W1974184735 creator A5015170367 @default.
• W1974184735 creator A5080297924 @default.
• W1974184735 creator A5088908386 @default.
• W1974184735 date "2014-09-02" @default.
• W1974184735 modified "2023-10-01" @default.
• W1974184735 title "Cellular Cholesterol Transport Proteins in Diabetic Nephropathy" @default.
• W1974184735 cites W1569572235 @default.
• W1974184735 cites W1982554330 @default.
• W1974184735 cites W1986605833 @default.
• W1974184735 cites W1988838635 @default.
• W1974184735 cites W1989242866 @default.
• W1974184735 cites W1996173827 @default.
• W1974184735 cites W1996372969 @default.
• W1974184735 cites W2018372725 @default.
• W1974184735 cites W2027842688 @default.
• W1974184735 cites W2040301789 @default.
• W1974184735 cites W2041962835 @default.
• W1974184735 cites W2048057789 @default.
• W1974184735 cites W2066521555 @default.
• W1974184735 cites W2072273844 @default.
• W1974184735 cites W2079110191 @default.
• W1974184735 cites W2093458935 @default.
• W1974184735 cites W2114311313 @default.
• W1974184735 cites W2116111086 @default.
• W1974184735 cites W2131640741 @default.
• W1974184735 cites W2131752045 @default.
• W1974184735 cites W2145989568 @default.
• W1974184735 cites W2148718682 @default.
• W1974184735 cites W2150438639 @default.
• W1974184735 doi "https://doi.org/10.1371/journal.pone.0105787" @default.
• W1974184735 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4152117" @default.
• W1974184735 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25181357" @default.
• W1974184735 hasPublicationYear "2014" @default.
• W1974184735 type Work @default.
• W1974184735 sameAs 1974184735 @default.
• W1974184735 citedByCount "38" @default.
• W1974184735 countsByYear W19741847352015 @default.
• W1974184735 countsByYear W19741847352016 @default.
• W1974184735 countsByYear W19741847352017 @default.
• W1974184735 countsByYear W19741847352018 @default.
• W1974184735 countsByYear W19741847352019 @default.
• W1974184735 countsByYear W19741847352020 @default.
• W1974184735 countsByYear W19741847352021 @default.
• W1974184735 countsByYear W19741847352022 @default.
• W1974184735 countsByYear W19741847352023 @default.
• W1974184735 crossrefType "journal-article" @default.
• W1974184735 hasAuthorship W1974184735A5010329388 @default.
• W1974184735 hasAuthorship W1974184735A5011859890 @default.
• W1974184735 hasAuthorship W1974184735A5013826550 @default.
• W1974184735 hasAuthorship W1974184735A5015170367 @default.
• W1974184735 hasAuthorship W1974184735A5080297924 @default.
• W1974184735 hasAuthorship W1974184735A5088908386 @default.
• W1974184735 hasBestOaLocation W19741847351 @default.
• W1974184735 hasConcept C104317684 @default.
• W1974184735 hasConcept C110459506 @default.
• W1974184735 hasConcept C126322002 @default.
• W1974184735 hasConcept C134018914 @default.
• W1974184735 hasConcept C149011108 @default.
• W1974184735 hasConcept C167400880 @default.
• W1974184735 hasConcept C185592680 @default.
• W1974184735 hasConcept C2776330080 @default.
• W1974184735 hasConcept C2777704780 @default.
• W1974184735 hasConcept C2778163477 @default.
• W1974184735 hasConcept C2779922275 @default.
• W1974184735 hasConcept C2780072125 @default.
• W1974184735 hasConcept C2780091579 @default.
• W1974184735 hasConcept C2781184683 @default.
• W1974184735 hasConcept C41443022 @default.
• W1974184735 hasConcept C55493867 @default.
• W1974184735 hasConcept C555293320 @default.
• W1974184735 hasConcept C63932345 @default.
• W1974184735 hasConcept C71924100 @default.
• W1974184735 hasConcept C86339819 @default.
• W1974184735 hasConcept C86803240 @default.
• W1974184735 hasConceptScore W1974184735C104317684 @default.
• W1974184735 hasConceptScore W1974184735C110459506 @default.
• W1974184735 hasConceptScore W1974184735C126322002 @default.
• W1974184735 hasConceptScore W1974184735C134018914 @default.
• W1974184735 hasConceptScore W1974184735C149011108 @default.
• W1974184735 hasConceptScore W1974184735C167400880 @default.
• W1974184735 hasConceptScore W1974184735C185592680 @default.
• W1974184735 hasConceptScore W1974184735C2776330080 @default.
• W1974184735 hasConceptScore W1974184735C2777704780 @default.
• W1974184735 hasConceptScore W1974184735C2778163477 @default.
• W1974184735 hasConceptScore W1974184735C2779922275 @default.
• W1974184735 hasConceptScore W1974184735C2780072125 @default.
• W1974184735 hasConceptScore W1974184735C2780091579 @default.
• W1974184735 hasConceptScore W1974184735C2781184683 @default.
• W1974184735 hasConceptScore W1974184735C41443022 @default.
• W1974184735 hasConceptScore W1974184735C55493867 @default.
• W1974184735 hasConceptScore W1974184735C555293320 @default.
• W1974184735 hasConceptScore W1974184735C63932345 @default.
• W1974184735 hasConceptScore W1974184735C71924100 @default.

• next