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- W1974195031 abstract "1 In the portal vein of permanently cannulated, freely moving, unanaesthetized rats, methacholine (MCh) is able to inhibit the electrically-evoked endogenous noradrenaline (NA) overflow. This inhibition is mediated by presynaptic inhibitory muscarinic heteroreceptors. 2 By use of pirenzepine, 4-diphenylacetoxy-N-methylpiperidine methobromide (4-DAMP) and AF-DX 116 as M1-, M3-, and M2-selective antagonists respectively, the MCh (0.1 μm)-induced inhibition of the electrically-evoked NA overflow could be reversed to the control stimulation value dose-dependently. 3 The potency order of the antagonists was: 4-DAMP > AF-DX 116 > pirenzepine, pIC50 values being 8.50, 7.96 and 7.01, respectively. 4 From these results it was concluded that the inhibitory presynaptic heteroreceptors in the portal vein of concious unrestrained rats are of the cardiac M2-subtype." @default.
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- W1974195031 date "1990-02-01" @default.
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- W1974195031 title "Characterization of presynaptic vascular muscarinic receptors inhibiting endogenous noradrenaline overflow in the portal vein of the freely moving rat" @default.
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- W1974195031 doi "https://doi.org/10.1111/j.1476-5381.1990.tb14684.x" @default.
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