Matches in SemOpenAlex for { <https://semopenalex.org/work/W1974216834> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W1974216834 endingPage "343" @default.
- W1974216834 startingPage "338" @default.
- W1974216834 abstract "PurposeWe present an approach to prioritize single nucleotide polymorphisms for further follow-up in genome-wide association studies of type 2 diabetes.MethodThe proposed method combines both the use of open data access from two type 2 diabetes-genome-wide association studies (granted by the Diabetes Genetics Initiative and the Welcome Trust Case Control Consortium) and the comprehensive analysis of candidate regions generated by the freely accessible ENDEAVOUR software.ResultsThe algorithm prioritized all genes of the whole genome in relation to type 2 diabetes. There were six of 1096 single nucleotide polymorphisms in five genes potentially associated with type 2 diabetes: tachykinin receptor 3 (rs1384401), anaplastic lymphoma receptor tyrosine kinase (rs4319896), calcium channel, voltage-dependent, L type, alpha 1D subunit (rs12487452), FOXO1A (rs10507486 and rs7323267), and v-akt murine thymoma viral oncogene homolog 3 (rs897959). We estimated the fixed effect and P values of each single nucleotide polymorphism in the combined dataset by Mantel-Haenszel meta-analysis and we observed significant P values for all single nucleotide polymorphisms except for rs897959 at v-akt murine thymoma viral oncogene homolog 3.ConclusionThe proposed strategy may be used as an alternative tool for optimizing the information of the nearly 500,000 gene variants in which markers with modest significant P value for disease association are currently disregarded. Additionally, the said single nucleotide polymorphisms may be incorporated into the replication of the multistage design involved in the genome-wide association studies." @default.
- W1974216834 created "2016-06-24" @default.
- W1974216834 creator A5014278453 @default.
- W1974216834 creator A5020854952 @default.
- W1974216834 creator A5035354017 @default.
- W1974216834 creator A5044747956 @default.
- W1974216834 date "2009-05-01" @default.
- W1974216834 modified "2023-10-18" @default.
- W1974216834 title "Gene prioritization based on biological plausibility over genome wide association studies renders new loci associated with type 2 diabetes" @default.
- W1974216834 cites W1944558458 @default.
- W1974216834 cites W1978215768 @default.
- W1974216834 cites W1988141914 @default.
- W1974216834 cites W2022636224 @default.
- W1974216834 cites W2027601065 @default.
- W1974216834 cites W2048755332 @default.
- W1974216834 cites W2070138234 @default.
- W1974216834 cites W2073184521 @default.
- W1974216834 cites W2080249321 @default.
- W1974216834 cites W2081359005 @default.
- W1974216834 cites W2082122713 @default.
- W1974216834 cites W2103101787 @default.
- W1974216834 cites W2109555487 @default.
- W1974216834 cites W2124478432 @default.
- W1974216834 cites W2125435699 @default.
- W1974216834 cites W2130613040 @default.
- W1974216834 cites W2134783591 @default.
- W1974216834 cites W2147297045 @default.
- W1974216834 cites W2152182117 @default.
- W1974216834 cites W2169486314 @default.
- W1974216834 cites W2333053580 @default.
- W1974216834 doi "https://doi.org/10.1097/gim.0b013e31819995ca" @default.
- W1974216834 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19346957" @default.
- W1974216834 hasPublicationYear "2009" @default.
- W1974216834 type Work @default.
- W1974216834 sameAs 1974216834 @default.
- W1974216834 citedByCount "16" @default.
- W1974216834 countsByYear W19742168342012 @default.
- W1974216834 countsByYear W19742168342013 @default.
- W1974216834 countsByYear W19742168342015 @default.
- W1974216834 countsByYear W19742168342017 @default.
- W1974216834 countsByYear W19742168342019 @default.
- W1974216834 countsByYear W19742168342020 @default.
- W1974216834 countsByYear W19742168342023 @default.
- W1974216834 crossrefType "journal-article" @default.
- W1974216834 hasAuthorship W1974216834A5014278453 @default.
- W1974216834 hasAuthorship W1974216834A5020854952 @default.
- W1974216834 hasAuthorship W1974216834A5035354017 @default.
- W1974216834 hasAuthorship W1974216834A5044747956 @default.
- W1974216834 hasBestOaLocation W19742168341 @default.
- W1974216834 hasConcept C104317684 @default.
- W1974216834 hasConcept C106208931 @default.
- W1974216834 hasConcept C134018914 @default.
- W1974216834 hasConcept C135763542 @default.
- W1974216834 hasConcept C141231307 @default.
- W1974216834 hasConcept C153209595 @default.
- W1974216834 hasConcept C186413461 @default.
- W1974216834 hasConcept C2777180221 @default.
- W1974216834 hasConcept C54355233 @default.
- W1974216834 hasConcept C555293320 @default.
- W1974216834 hasConcept C70721500 @default.
- W1974216834 hasConcept C86803240 @default.
- W1974216834 hasConceptScore W1974216834C104317684 @default.
- W1974216834 hasConceptScore W1974216834C106208931 @default.
- W1974216834 hasConceptScore W1974216834C134018914 @default.
- W1974216834 hasConceptScore W1974216834C135763542 @default.
- W1974216834 hasConceptScore W1974216834C141231307 @default.
- W1974216834 hasConceptScore W1974216834C153209595 @default.
- W1974216834 hasConceptScore W1974216834C186413461 @default.
- W1974216834 hasConceptScore W1974216834C2777180221 @default.
- W1974216834 hasConceptScore W1974216834C54355233 @default.
- W1974216834 hasConceptScore W1974216834C555293320 @default.
- W1974216834 hasConceptScore W1974216834C70721500 @default.
- W1974216834 hasConceptScore W1974216834C86803240 @default.
- W1974216834 hasIssue "5" @default.
- W1974216834 hasLocation W19742168341 @default.
- W1974216834 hasLocation W19742168342 @default.
- W1974216834 hasOpenAccess W1974216834 @default.
- W1974216834 hasPrimaryLocation W19742168341 @default.
- W1974216834 hasRelatedWork W2065120962 @default.
- W1974216834 hasRelatedWork W2069221540 @default.
- W1974216834 hasRelatedWork W2092398847 @default.
- W1974216834 hasRelatedWork W2094455802 @default.
- W1974216834 hasRelatedWork W2517753256 @default.
- W1974216834 hasRelatedWork W2587112589 @default.
- W1974216834 hasRelatedWork W2884987722 @default.
- W1974216834 hasRelatedWork W3081400219 @default.
- W1974216834 hasRelatedWork W4223972846 @default.
- W1974216834 hasRelatedWork W4306392993 @default.
- W1974216834 hasVolume "11" @default.
- W1974216834 isParatext "false" @default.
- W1974216834 isRetracted "false" @default.
- W1974216834 magId "1974216834" @default.
- W1974216834 workType "article" @default.