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• W1974222768 endingPage "332" @default.
• W1974222768 startingPage "327" @default.
• W1974222768 abstract "Mouse oocytes suppress follicle-stimulating hormone (FSH)-induced luteinizing hormone receptor (LHR) messenger ribonucleic acid (mRNA) expression in cultured granulosa cells. The objective of this study was to assess the mechanism by which oocytes suppress FSH-induced LHR expression. The effect of cumulus cell-denuded, germinal-vesicle-stage oocytes, isolated from antral follicles, on FSH-induced cyclic adenosine monophosphate (cAMP) production by cultured granulosa cells was determined by radioimmunoassays. In addition, the effect of oocytes on 8Br-cAMP-induced LHR mRNA steady-state expression by granulosa cells was assessed by RNase protection assays. Oocytes had no detectable effect on FSH-induced cAMP production. However, oocytes dramatically suppressed 8Br-cAMP-induced LHR mRNA steady-state expression by granulosa cells. It was concluded that the mechanism by which oocytes suppress FSH-induced steady-state expression of LHR mRNA is not by inactivating FSH, preventing functional interactions of FSH with its granulosa cell receptors, or by interfering with the signal-transduction mechanisms required for FSH-dependent cAMP production. In addition, since oocytes suppressed the 8Br-cAMP-induced increase in steady-state expression of mRNA for LHR, oocyte-derived factors probably suppress expression by acting downstream of FSH-induced elevation of granulosa cell cAMP." @default.
• W1974222768 created "2016-06-24" @default.
• W1974222768 creator A5041744744 @default.
• W1974222768 creator A5052997039 @default.
• W1974222768 creator A5058334709 @default.
• W1974222768 date "1998-03-01" @default.
• W1974222768 modified "2023-10-09" @default.
• W1974222768 title "Mouse oocytes suppress cAMP-induced expression of LH receptor mRNA by granulosa cells in vitro" @default.
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• W1974222768 doi "https://doi.org/10.1002/(sici)1098-2795(199803)49:3<327::aid-mrd13>3.0.co;2-t" @default.
• W1974222768 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9491385" @default.
• W1974222768 hasPublicationYear "1998" @default.
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