Matches in SemOpenAlex for { <https://semopenalex.org/work/W1974231955> ?p ?o ?g. }
- W1974231955 endingPage "e78022" @default.
- W1974231955 startingPage "e78022" @default.
- W1974231955 abstract "Oral squamous cell carcinoma (OSCC) has a tendency to migrate and metastasize. WNT1-inducible signaling pathway protein 1 (WISP-1) is a cysteine-rich protein that belongs to the Cyr61, CTGF, Nov (CCN) family of matrix cellular proteins. The effect of WISP-1 on human OSCC cells, however, is unknown. Here, we showed that WISP-1 increased cell migration and intercellular adhesion molecule-1 (ICAM-1) expression in OSCC cells. Pretreatment of cells with integrin αvβ3 monoclonal antibody (mAb) significantly abolished WISP-1–induced cell migration and ICAM-1 expression. On the other hand, WISP-1–mediated cell motility and ICAM-1 upregulation were attenuated by ASK1, JNK, and p38 inhibitor. Furthermore, WISP-1 also enhanced activator protein 1 (AP-1) activation, and the integrin αvβ3 mAb, and ASK1, JNK, and p38 inhibitors reduced WISP-1–mediated AP-1 activation. Moreover, WISP-1 and ICAM-1 expression correlated with the tumor stage of patients with OSCC. Our results indicate that WISP-1 enhances the migration of OSCC cells by increasing ICAM-1 expression through the αvβ3 integrin receptor and the ASK1, JNK/p38, and AP-1 signal transduction pathways." @default.
- W1974231955 created "2016-06-24" @default.
- W1974231955 creator A5004668741 @default.
- W1974231955 creator A5009202383 @default.
- W1974231955 creator A5037456785 @default.
- W1974231955 creator A5058305068 @default.
- W1974231955 creator A5076096342 @default.
- W1974231955 date "2013-10-21" @default.
- W1974231955 modified "2023-09-27" @default.
- W1974231955 title "Apoptosis Signal-Regulating Kinase 1 Is Involved in WISP-1–Promoted Cell Motility in Human Oral Squamous Cell Carcinoma Cells" @default.
- W1974231955 cites W1530203607 @default.
- W1974231955 cites W1968725140 @default.
- W1974231955 cites W1979074939 @default.
- W1974231955 cites W1983777512 @default.
- W1974231955 cites W1984841510 @default.
- W1974231955 cites W1985582185 @default.
- W1974231955 cites W1994161105 @default.
- W1974231955 cites W2001805170 @default.
- W1974231955 cites W2003426260 @default.
- W1974231955 cites W2007080891 @default.
- W1974231955 cites W2018032064 @default.
- W1974231955 cites W2030015373 @default.
- W1974231955 cites W2030529446 @default.
- W1974231955 cites W2037871274 @default.
- W1974231955 cites W2040329036 @default.
- W1974231955 cites W2045595833 @default.
- W1974231955 cites W2046620357 @default.
- W1974231955 cites W2049976919 @default.
- W1974231955 cites W2077498058 @default.
- W1974231955 cites W2085292382 @default.
- W1974231955 cites W2089606295 @default.
- W1974231955 cites W2102148660 @default.
- W1974231955 cites W2104101394 @default.
- W1974231955 cites W2108065093 @default.
- W1974231955 cites W2108868980 @default.
- W1974231955 cites W2112509049 @default.
- W1974231955 cites W2112747265 @default.
- W1974231955 cites W2113704334 @default.
- W1974231955 cites W2114752142 @default.
- W1974231955 cites W2125013655 @default.
- W1974231955 cites W2134546428 @default.
- W1974231955 cites W2136998234 @default.
- W1974231955 cites W2140777225 @default.
- W1974231955 cites W2147000598 @default.
- W1974231955 cites W2158545941 @default.
- W1974231955 cites W2158708535 @default.
- W1974231955 cites W2161114499 @default.
- W1974231955 cites W2161656555 @default.
- W1974231955 cites W2169883682 @default.
- W1974231955 cites W2170963456 @default.
- W1974231955 cites W4254566517 @default.
- W1974231955 cites W4321429547 @default.
- W1974231955 doi "https://doi.org/10.1371/journal.pone.0078022" @default.
- W1974231955 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3804520" @default.
- W1974231955 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24205072" @default.
- W1974231955 hasPublicationYear "2013" @default.
- W1974231955 type Work @default.
- W1974231955 sameAs 1974231955 @default.
- W1974231955 citedByCount "38" @default.
- W1974231955 countsByYear W19742319552014 @default.
- W1974231955 countsByYear W19742319552015 @default.
- W1974231955 countsByYear W19742319552016 @default.
- W1974231955 countsByYear W19742319552017 @default.
- W1974231955 countsByYear W19742319552018 @default.
- W1974231955 countsByYear W19742319552019 @default.
- W1974231955 countsByYear W19742319552020 @default.
- W1974231955 countsByYear W19742319552021 @default.
- W1974231955 countsByYear W19742319552022 @default.
- W1974231955 countsByYear W19742319552023 @default.
- W1974231955 crossrefType "journal-article" @default.
- W1974231955 hasAuthorship W1974231955A5004668741 @default.
- W1974231955 hasAuthorship W1974231955A5009202383 @default.
- W1974231955 hasAuthorship W1974231955A5037456785 @default.
- W1974231955 hasAuthorship W1974231955A5058305068 @default.
- W1974231955 hasAuthorship W1974231955A5076096342 @default.
- W1974231955 hasBestOaLocation W19742319551 @default.
- W1974231955 hasConcept C124160383 @default.
- W1974231955 hasConcept C137738243 @default.
- W1974231955 hasConcept C1491633281 @default.
- W1974231955 hasConcept C170493617 @default.
- W1974231955 hasConcept C184235292 @default.
- W1974231955 hasConcept C185592680 @default.
- W1974231955 hasConcept C190283241 @default.
- W1974231955 hasConcept C195794163 @default.
- W1974231955 hasConcept C2775960820 @default.
- W1974231955 hasConcept C2778753947 @default.
- W1974231955 hasConcept C2780631158 @default.
- W1974231955 hasConcept C502942594 @default.
- W1974231955 hasConcept C51551487 @default.
- W1974231955 hasConcept C55493867 @default.
- W1974231955 hasConcept C57074206 @default.
- W1974231955 hasConcept C62478195 @default.
- W1974231955 hasConcept C85789140 @default.
- W1974231955 hasConcept C86803240 @default.
- W1974231955 hasConcept C90934575 @default.
- W1974231955 hasConcept C95444343 @default.
- W1974231955 hasConcept C97029542 @default.
- W1974231955 hasConceptScore W1974231955C124160383 @default.