FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1974248962> ?p ?o ?g. }

• W1974248962 endingPage "541" @default.
• W1974248962 startingPage "533" @default.
• W1974248962 abstract "Claudin-4, encoding a protein for tight junction formation and function, is highly overexpressed in pancreatic ductal adenocarcinoma and is also associated with invasive adenocarcinomas arising in intraductal papillary mucinous neoplasms of the pancreas. However, the expression pattern of claudin-4 during neoplastic progression of intraductal papillary mucinous neoplasms remains unknown. Using quantitative real-time reverse transcription-PCR, we analyzed claudin-4 mRNA in a panel of 14 pancreatic cancer cell lines and in formalin-fixed paraffin-embedded tissues from 80 patients with intraductal papillary mucinous neoplasms of different histological grades and papillary subtypes. Increased expression of claudin-4 was confirmed in all the pancreatic cancer cell lines tested as compared with normal ductal epithelial cells and fibroblast cultures. The claudin-4 expression was significantly higher in high-grade intraductal papillary mucinous neoplasms (borderline neoplasm and carcinoma) than in low-grade intraductal papillary mucinous neoplasms (adenoma) (P<0.0001). In addition, claudin-4 mRNA levels were significantly higher in intestinal-type intraductal papillary mucinous neoplasms than in non-intestinal-type intraductal papillary mucinous neoplasms based on papillary subclassification (P<0.0001). Our findings suggest that claudin-4 expression is associated with neoplastic progression of intraductal papillary mucinous neoplasms and, especially, with a distinct pathway to intestinal differentiation." @default.
• W1974248962 created "2016-06-24" @default.
• W1974248962 creator A5020122344 @default.
• W1974248962 creator A5020689879 @default.
• W1974248962 creator A5022595821 @default.
• W1974248962 creator A5041295383 @default.
• W1974248962 creator A5059808377 @default.
• W1974248962 creator A5065375856 @default.
• W1974248962 creator A5073110042 @default.
• W1974248962 creator A5078000437 @default.
• W1974248962 creator A5078409741 @default.
• W1974248962 creator A5085781479 @default.
• W1974248962 date "2011-04-01" @default.
• W1974248962 modified "2023-10-15" @default.
• W1974248962 title "Expression of claudin-4 (CLDN4) mRNA in intraductal papillary mucinous neoplasms of the pancreas" @default.
• W1974248962 cites W1926327739 @default.
• W1974248962 cites W1966184698 @default.
• W1974248962 cites W1984676170 @default.
• W1974248962 cites W1993728532 @default.
• W1974248962 cites W2000720699 @default.
• W1974248962 cites W2016181047 @default.
• W1974248962 cites W2020480128 @default.
• W1974248962 cites W2022195700 @default.
• W1974248962 cites W2034626424 @default.
• W1974248962 cites W2039357620 @default.
• W1974248962 cites W2050386266 @default.
• W1974248962 cites W2056685208 @default.
• W1974248962 cites W2064252617 @default.
• W1974248962 cites W2065725084 @default.
• W1974248962 cites W2067072464 @default.
• W1974248962 cites W2073120376 @default.
• W1974248962 cites W2087677309 @default.
• W1974248962 cites W2094596799 @default.
• W1974248962 cites W2095412389 @default.
• W1974248962 cites W2100014692 @default.
• W1974248962 cites W2130981598 @default.
• W1974248962 cites W2134226456 @default.
• W1974248962 cites W2138566698 @default.
• W1974248962 cites W2144912834 @default.
• W1974248962 cites W2149121581 @default.
• W1974248962 cites W2163719351 @default.
• W1974248962 cites W2292911347 @default.
• W1974248962 doi "https://doi.org/10.1038/modpathol.2010.218" @default.
• W1974248962 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21102412" @default.
• W1974248962 hasPublicationYear "2011" @default.
• W1974248962 type Work @default.
• W1974248962 sameAs 1974248962 @default.
• W1974248962 citedByCount "17" @default.
• W1974248962 countsByYear W19742489622012 @default.
• W1974248962 countsByYear W19742489622013 @default.
• W1974248962 countsByYear W19742489622014 @default.
• W1974248962 countsByYear W19742489622016 @default.
• W1974248962 countsByYear W19742489622017 @default.
• W1974248962 countsByYear W19742489622018 @default.
• W1974248962 countsByYear W19742489622020 @default.
• W1974248962 countsByYear W19742489622022 @default.
• W1974248962 countsByYear W19742489622023 @default.
• W1974248962 crossrefType "journal-article" @default.
• W1974248962 hasAuthorship W1974248962A5020122344 @default.
• W1974248962 hasAuthorship W1974248962A5020689879 @default.
• W1974248962 hasAuthorship W1974248962A5022595821 @default.
• W1974248962 hasAuthorship W1974248962A5041295383 @default.
• W1974248962 hasAuthorship W1974248962A5059808377 @default.
• W1974248962 hasAuthorship W1974248962A5065375856 @default.
• W1974248962 hasAuthorship W1974248962A5073110042 @default.
• W1974248962 hasAuthorship W1974248962A5078000437 @default.
• W1974248962 hasAuthorship W1974248962A5078409741 @default.
• W1974248962 hasAuthorship W1974248962A5085781479 @default.
• W1974248962 hasBestOaLocation W19742489621 @default.
• W1974248962 hasConcept C121608353 @default.
• W1974248962 hasConcept C126322002 @default.
• W1974248962 hasConcept C142724271 @default.
• W1974248962 hasConcept C177779419 @default.
• W1974248962 hasConcept C2776469228 @default.
• W1974248962 hasConcept C2777874381 @default.
• W1974248962 hasConcept C2778764654 @default.
• W1974248962 hasConcept C2781182431 @default.
• W1974248962 hasConcept C2909866369 @default.
• W1974248962 hasConcept C502942594 @default.
• W1974248962 hasConcept C51872919 @default.
• W1974248962 hasConcept C71924100 @default.
• W1974248962 hasConcept C86803240 @default.
• W1974248962 hasConcept C95444343 @default.
• W1974248962 hasConceptScore W1974248962C121608353 @default.
• W1974248962 hasConceptScore W1974248962C126322002 @default.
• W1974248962 hasConceptScore W1974248962C142724271 @default.
• W1974248962 hasConceptScore W1974248962C177779419 @default.
• W1974248962 hasConceptScore W1974248962C2776469228 @default.
• W1974248962 hasConceptScore W1974248962C2777874381 @default.
• W1974248962 hasConceptScore W1974248962C2778764654 @default.
• W1974248962 hasConceptScore W1974248962C2781182431 @default.
• W1974248962 hasConceptScore W1974248962C2909866369 @default.
• W1974248962 hasConceptScore W1974248962C502942594 @default.
• W1974248962 hasConceptScore W1974248962C51872919 @default.
• W1974248962 hasConceptScore W1974248962C71924100 @default.
• W1974248962 hasConceptScore W1974248962C86803240 @default.
• W1974248962 hasConceptScore W1974248962C95444343 @default.
• W1974248962 hasIssue "4" @default.

• next