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- W1974251150 abstract "Mammography is the primary imaging tool for screening and diagnosis of human breast cancers, but ~10-20% of palpable tumors are not detectable on mammograms and only about 40% of biopsied lesions are malignant. Here we report a high-resolution, low-dose phase contrast X-ray tomographic method for 3D diagnosis of human breast cancers. By combining phase contrast X-ray imaging with an image reconstruction method known as equally sloped tomography, we imaged a human breast in three dimensions and identified a malignant cancer with a pixel size of 92 μm and a radiation dose less than that of dual-view mammography. According to a blind evaluation by five independent radiologists, our method can reduce the radiation dose and acquisition time by ~74% relative to conventional phase contrast X-ray tomography, while maintaining high image resolution and image contrast. These results demonstrate that high-resolution 3D diagnostic imaging of human breast cancers can, in principle, be performed at clinical compatible doses." @default.
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- W1974251150 date "2012-09-28" @default.
- W1974251150 modified "2023-10-01" @default.
- W1974251150 title "High-resolution, low-dose phase contrast X-ray tomography for 3D diagnosis of human breast cancers" @default.
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- W1974251150 doi "https://doi.org/10.1073/pnas.1204460109" @default.
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