Matches in SemOpenAlex for { <https://semopenalex.org/work/W1974271424> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W1974271424 endingPage "842" @default.
- W1974271424 startingPage "837" @default.
- W1974271424 abstract "We examined the basis of the all or none difference in inducing melanocytic tumor development among three transgenic mouse lines (304, 192 and 242) to which the same promoter-enhancer (metallothionein-I) and oncogene (ret) were introduced. We initially demonstrated that both skin melanosis and Ret protein expression in skin, thymus and brain first became detectable before or immediately after birth in the mice of the tumor developing lines (304 and 192), whereas they became detectable a few days after birth in the mice of the non-tumor developing line (242) by Western blotting and immunohistochemical analysis. Interestingly, the Ret protein expression in skin developed rapidly after birth as a burst with peak levels on 0.5-1.5 day newborns of lines 304 and 192 and on 7.0-7.5 day-old mice of line 242. The levels of autophosphorylation of Ret kinase in skin were, however, invariable among these three transgenic mouse lines. The mice of line 242, but not those of lines 192 and 304, responded to Ret protein immunization by increased antigen-dependent lymphocyte proliferation and T-cell-mediated tumor growth suppression in vitro. Furthermore, ret-transgenic mice of line 242, but not line 304, rejected the subcutaneously transplanted tumors that had originally developed in a mouse of line 304. These results suggest that whether oncogene product-specific-tolerance is established or not to antitumor immunity may be decided by the dynamics of ret oncogene expression before and after delivery and this is the primary factor determining development or non-development of melanoma." @default.
- W1974271424 created "2016-06-24" @default.
- W1974271424 creator A5013840206 @default.
- W1974271424 creator A5016109322 @default.
- W1974271424 creator A5038550258 @default.
- W1974271424 creator A5044404332 @default.
- W1974271424 creator A5044537294 @default.
- W1974271424 creator A5048038268 @default.
- W1974271424 creator A5049050220 @default.
- W1974271424 creator A5063960911 @default.
- W1974271424 creator A5071037763 @default.
- W1974271424 creator A5089988781 @default.
- W1974271424 date "1999-01-21" @default.
- W1974271424 modified "2023-10-18" @default.
- W1974271424 title "Linkage between melanocytic tumor development and early burst of Ret protein expression for tolerance induction in metallothionein-I/ret transgenic mouse lines" @default.
- W1974271424 cites W1511759207 @default.
- W1974271424 cites W1547700243 @default.
- W1974271424 cites W1629158872 @default.
- W1974271424 cites W1966064095 @default.
- W1974271424 cites W1969299399 @default.
- W1974271424 cites W1986267292 @default.
- W1974271424 cites W2011724423 @default.
- W1974271424 cites W2031281936 @default.
- W1974271424 cites W2041601304 @default.
- W1974271424 cites W2045945832 @default.
- W1974271424 cites W2054727572 @default.
- W1974271424 cites W2118407508 @default.
- W1974271424 cites W2139680027 @default.
- W1974271424 cites W2140672059 @default.
- W1974271424 cites W4313310712 @default.
- W1974271424 doi "https://doi.org/10.1038/sj.onc.1202329" @default.
- W1974271424 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9989837" @default.
- W1974271424 hasPublicationYear "1999" @default.
- W1974271424 type Work @default.
- W1974271424 sameAs 1974271424 @default.
- W1974271424 citedByCount "38" @default.
- W1974271424 countsByYear W19742714242012 @default.
- W1974271424 countsByYear W19742714242013 @default.
- W1974271424 countsByYear W19742714242014 @default.
- W1974271424 countsByYear W19742714242015 @default.
- W1974271424 countsByYear W19742714242016 @default.
- W1974271424 countsByYear W19742714242020 @default.
- W1974271424 crossrefType "journal-article" @default.
- W1974271424 hasAuthorship W1974271424A5013840206 @default.
- W1974271424 hasAuthorship W1974271424A5016109322 @default.
- W1974271424 hasAuthorship W1974271424A5038550258 @default.
- W1974271424 hasAuthorship W1974271424A5044404332 @default.
- W1974271424 hasAuthorship W1974271424A5044537294 @default.
- W1974271424 hasAuthorship W1974271424A5048038268 @default.
- W1974271424 hasAuthorship W1974271424A5049050220 @default.
- W1974271424 hasAuthorship W1974271424A5063960911 @default.
- W1974271424 hasAuthorship W1974271424A5071037763 @default.
- W1974271424 hasAuthorship W1974271424A5089988781 @default.
- W1974271424 hasBestOaLocation W19742714241 @default.
- W1974271424 hasConcept C102230213 @default.
- W1974271424 hasConcept C104317684 @default.
- W1974271424 hasConcept C121608353 @default.
- W1974271424 hasConcept C141035611 @default.
- W1974271424 hasConcept C153911025 @default.
- W1974271424 hasConcept C203014093 @default.
- W1974271424 hasConcept C2781018059 @default.
- W1974271424 hasConcept C29537977 @default.
- W1974271424 hasConcept C502942594 @default.
- W1974271424 hasConcept C54355233 @default.
- W1974271424 hasConcept C81885089 @default.
- W1974271424 hasConcept C86803240 @default.
- W1974271424 hasConceptScore W1974271424C102230213 @default.
- W1974271424 hasConceptScore W1974271424C104317684 @default.
- W1974271424 hasConceptScore W1974271424C121608353 @default.
- W1974271424 hasConceptScore W1974271424C141035611 @default.
- W1974271424 hasConceptScore W1974271424C153911025 @default.
- W1974271424 hasConceptScore W1974271424C203014093 @default.
- W1974271424 hasConceptScore W1974271424C2781018059 @default.
- W1974271424 hasConceptScore W1974271424C29537977 @default.
- W1974271424 hasConceptScore W1974271424C502942594 @default.
- W1974271424 hasConceptScore W1974271424C54355233 @default.
- W1974271424 hasConceptScore W1974271424C81885089 @default.
- W1974271424 hasConceptScore W1974271424C86803240 @default.
- W1974271424 hasIssue "3" @default.
- W1974271424 hasLocation W19742714241 @default.
- W1974271424 hasLocation W19742714242 @default.
- W1974271424 hasOpenAccess W1974271424 @default.
- W1974271424 hasPrimaryLocation W19742714241 @default.
- W1974271424 hasRelatedWork W1536426327 @default.
- W1974271424 hasRelatedWork W1973459962 @default.
- W1974271424 hasRelatedWork W2030084515 @default.
- W1974271424 hasRelatedWork W2064668712 @default.
- W1974271424 hasRelatedWork W2070974215 @default.
- W1974271424 hasRelatedWork W2158124286 @default.
- W1974271424 hasRelatedWork W2398991683 @default.
- W1974271424 hasRelatedWork W2407241705 @default.
- W1974271424 hasRelatedWork W2413400652 @default.
- W1974271424 hasRelatedWork W51112303 @default.
- W1974271424 hasVolume "18" @default.
- W1974271424 isParatext "false" @default.
- W1974271424 isRetracted "false" @default.
- W1974271424 magId "1974271424" @default.
- W1974271424 workType "article" @default.