FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1974280276> ?p ?o ?g. }

• W1974280276 endingPage "138" @default.
• W1974280276 startingPage "132" @default.
• W1974280276 abstract "The HLA-B27 molecule is strongly associated with the spondyloarthropathies, a group of chronic inflammatory diseases, affecting the skeleton, the bowel and the skin. This association has been largely studied, but mechanisms of pathology remain unclear. The HLA-B27 transgenic rats develop a spontaneous disease that strikingly resembles human spondyloarthropathies, dependent of bacterial flora and implicating the immune system. The presence of CD4+ T cells is required, and antigen presenting cells (APC) expressing high levels of HLA-B27 likely play an important role. Indeed, APC are defective in naive T lymphocytes stimulation. This default appears to implicate the APC/T cells contact, and may result in a loss of tolerance toward microbial flora. Two models of skeletal inflammation linked to HLA-B27 have been developed in mice. The ANKENT mice develop a spontaneous ossifying enthesitis affecting ankle and tarsal joints, with increased frequency in the presence of an HLA-B27 transgene. The HLA-B27 transgenic mice lacking endogenous β2 microglobulin develop arthritis of hind-paws. In this model, homodimers of B27 heavy chains could be implicated in the pathogenesis by presenting exogenous peptides to CD4+ T cells." @default.
• W1974280276 created "2016-06-24" @default.
• W1974280276 creator A5008206718 @default.
• W1974280276 creator A5039807632 @default.
• W1974280276 creator A5057460230 @default.
• W1974280276 date "2006-03-01" @default.
• W1974280276 modified "2023-10-18" @default.
• W1974280276 title "Animal models of HLA-B27-associated diseases: new outcomes" @default.
• W1974280276 cites W1502820929 @default.
• W1974280276 cites W1541707305 @default.
• W1974280276 cites W1669999648 @default.
• W1974280276 cites W1899226846 @default.
• W1974280276 cites W1934831354 @default.
• W1974280276 cites W1970077833 @default.
• W1974280276 cites W1974823499 @default.
• W1974280276 cites W1986106414 @default.
• W1974280276 cites W1988829774 @default.
• W1974280276 cites W1993999106 @default.
• W1974280276 cites W1999078465 @default.
• W1974280276 cites W2000804548 @default.
• W1974280276 cites W2001878265 @default.
• W1974280276 cites W2017242640 @default.
• W1974280276 cites W2021867336 @default.
• W1974280276 cites W2027698427 @default.
• W1974280276 cites W2034298592 @default.
• W1974280276 cites W2036198672 @default.
• W1974280276 cites W2040549990 @default.
• W1974280276 cites W2041511764 @default.
• W1974280276 cites W2058722206 @default.
• W1974280276 cites W2062479205 @default.
• W1974280276 cites W2064057132 @default.
• W1974280276 cites W2067249142 @default.
• W1974280276 cites W2067257520 @default.
• W1974280276 cites W2070062311 @default.
• W1974280276 cites W2076058809 @default.
• W1974280276 cites W2079923627 @default.
• W1974280276 cites W2080053265 @default.
• W1974280276 cites W2080757497 @default.
• W1974280276 cites W2081187098 @default.
• W1974280276 cites W2089962384 @default.
• W1974280276 cites W2090443272 @default.
• W1974280276 cites W2094109363 @default.
• W1974280276 cites W2100022322 @default.
• W1974280276 cites W2105296887 @default.
• W1974280276 cites W2111256698 @default.
• W1974280276 cites W2114959057 @default.
• W1974280276 cites W2117901432 @default.
• W1974280276 cites W2136931197 @default.
• W1974280276 cites W2137109050 @default.
• W1974280276 cites W2141021930 @default.
• W1974280276 cites W2147396727 @default.
• W1974280276 cites W2151916979 @default.
• W1974280276 cites W4313333783 @default.
• W1974280276 doi "https://doi.org/10.1016/j.jbspin.2005.03.016" @default.
• W1974280276 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16377230" @default.
• W1974280276 hasPublicationYear "2006" @default.
• W1974280276 type Work @default.
• W1974280276 sameAs 1974280276 @default.
• W1974280276 citedByCount "36" @default.
• W1974280276 countsByYear W19742802762012 @default.
• W1974280276 countsByYear W19742802762013 @default.
• W1974280276 countsByYear W19742802762014 @default.
• W1974280276 countsByYear W19742802762015 @default.
• W1974280276 countsByYear W19742802762016 @default.
• W1974280276 countsByYear W19742802762017 @default.
• W1974280276 countsByYear W19742802762018 @default.
• W1974280276 countsByYear W19742802762020 @default.
• W1974280276 countsByYear W19742802762021 @default.
• W1974280276 countsByYear W19742802762022 @default.
• W1974280276 countsByYear W19742802762023 @default.
• W1974280276 crossrefType "journal-article" @default.
• W1974280276 hasAuthorship W1974280276A5008206718 @default.
• W1974280276 hasAuthorship W1974280276A5039807632 @default.
• W1974280276 hasAuthorship W1974280276A5057460230 @default.
• W1974280276 hasConcept C102230213 @default.
• W1974280276 hasConcept C104317684 @default.
• W1974280276 hasConcept C141035611 @default.
• W1974280276 hasConcept C147483822 @default.
• W1974280276 hasConcept C188280979 @default.
• W1974280276 hasConcept C203014093 @default.
• W1974280276 hasConcept C2776914184 @default.
• W1974280276 hasConcept C2777077863 @default.
• W1974280276 hasConcept C2778091532 @default.
• W1974280276 hasConcept C2780942790 @default.
• W1974280276 hasConcept C54355233 @default.
• W1974280276 hasConcept C71924100 @default.
• W1974280276 hasConcept C86803240 @default.
• W1974280276 hasConcept C8891405 @default.
• W1974280276 hasConceptScore W1974280276C102230213 @default.
• W1974280276 hasConceptScore W1974280276C104317684 @default.
• W1974280276 hasConceptScore W1974280276C141035611 @default.
• W1974280276 hasConceptScore W1974280276C147483822 @default.
• W1974280276 hasConceptScore W1974280276C188280979 @default.
• W1974280276 hasConceptScore W1974280276C203014093 @default.
• W1974280276 hasConceptScore W1974280276C2776914184 @default.
• W1974280276 hasConceptScore W1974280276C2777077863 @default.
• W1974280276 hasConceptScore W1974280276C2778091532 @default.
• W1974280276 hasConceptScore W1974280276C2780942790 @default.

• next