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- W1974317938 endingPage "31" @default.
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- W1974317938 abstract "Past research into the pathogenesis of RA has generally concerned itself with established inflammation. The present review summarizes alterations in microvascular anatomy and function which occur during the hypoxic state, in various experimental and disease conditions. It further shows that tissue hypoxia is a common finding in RA and that the microvascular alterations of RA are similar to those produced by experimental hypoxia. The available data suggest that microcirculatory compromise, concomitant with an increase in metabolic needs of synovial tissue, may initiate tissue injury via anoxia and acidosis, resulting in hydrolytic enzyme release, increased vascular permeability and acceleration of inflammatory processes. It is further believed that the microcirculatory abnormality may be generalized, accounting for the systemic manifestations often seen in RA. Factors effecting arteriolar blood flow obstruction are reviewed to identify areas for future investigation in RA and other disorders involving microvasculopathy. The multitude of longknown and newly recognized factors predisposing to vasospasm and vasodilatation have been outlined as a guide to possible mechanisms which may be operative in RA. An attempt has been made to gather and synthesize the available data in the hope that it may stimulate other investigators to pursue more definitive research into specific areas which may show early microvascular abnormalities in the pathophysiology of RA. Identification of factors operative early in the pathogenesis of RA, before it becomes self-perpetuating, may well be a step in the direction of preventing the ravages of this disease, or providing insight to more effective control." @default.
- W1974317938 created "2016-06-24" @default.
- W1974317938 creator A5039387098 @default.
- W1974317938 creator A5050521133 @default.
- W1974317938 date "1982-08-01" @default.
- W1974317938 modified "2023-09-25" @default.
- W1974317938 title "Pathogenesis of rheumatoid arthritis: A vascular hypothesis" @default.
- W1974317938 cites W1527025885 @default.
- W1974317938 cites W1571804905 @default.
- W1974317938 cites W157749846 @default.
- W1974317938 cites W1578963873 @default.
- W1974317938 cites W1597429457 @default.
- W1974317938 cites W1601102876 @default.
- W1974317938 cites W1723349763 @default.
- W1974317938 cites W1750690213 @default.
- W1974317938 cites W176304266 @default.
- W1974317938 cites W1824675238 @default.
- W1974317938 cites W1834650296 @default.
- W1974317938 cites W1964373752 @default.
- W1974317938 cites W1964446232 @default.
- W1974317938 cites W1964600044 @default.
- W1974317938 cites W1964690014 @default.
- W1974317938 cites W1965324641 @default.
- W1974317938 cites W1966299443 @default.
- W1974317938 cites W1966927057 @default.
- W1974317938 cites W1968541191 @default.
- W1974317938 cites W1969488647 @default.
- W1974317938 cites W1970115314 @default.
- W1974317938 cites W1970274988 @default.
- W1974317938 cites W1970623516 @default.
- W1974317938 cites W1970644801 @default.
- W1974317938 cites W1972066963 @default.
- W1974317938 cites W1973987071 @default.
- W1974317938 cites W1975423332 @default.
- W1974317938 cites W1976551582 @default.
- W1974317938 cites W1976912963 @default.
- W1974317938 cites W1977723745 @default.
- W1974317938 cites W1979014586 @default.
- W1974317938 cites W1982230371 @default.
- W1974317938 cites W1982447241 @default.
- W1974317938 cites W1982823087 @default.
- W1974317938 cites W1983480547 @default.
- W1974317938 cites W1984991163 @default.
- W1974317938 cites W1986130310 @default.
- W1974317938 cites W1987424145 @default.
- W1974317938 cites W1989323526 @default.
- W1974317938 cites W1990250652 @default.
- W1974317938 cites W1990628113 @default.
- W1974317938 cites W1990862468 @default.
- W1974317938 cites W1992408273 @default.
- W1974317938 cites W1994135303 @default.
- W1974317938 cites W1994917175 @default.
- W1974317938 cites W1995695303 @default.
- W1974317938 cites W1996719698 @default.
- W1974317938 cites W1996892530 @default.
- W1974317938 cites W1996942330 @default.
- W1974317938 cites W1998433588 @default.
- W1974317938 cites W2000225343 @default.
- W1974317938 cites W2000461238 @default.
- W1974317938 cites W2001220917 @default.
- W1974317938 cites W2002894423 @default.
- W1974317938 cites W2003414760 @default.
- W1974317938 cites W2004479034 @default.
- W1974317938 cites W2004712976 @default.
- W1974317938 cites W2004800099 @default.
- W1974317938 cites W2005984152 @default.
- W1974317938 cites W2005986988 @default.
- W1974317938 cites W2006795909 @default.
- W1974317938 cites W2006927487 @default.
- W1974317938 cites W2007374353 @default.
- W1974317938 cites W2008440251 @default.
- W1974317938 cites W2008644864 @default.
- W1974317938 cites W2009959756 @default.
- W1974317938 cites W2010809545 @default.
- W1974317938 cites W2011940076 @default.
- W1974317938 cites W2013649386 @default.
- W1974317938 cites W2014703688 @default.
- W1974317938 cites W2015235160 @default.
- W1974317938 cites W2015893655 @default.
- W1974317938 cites W2017185210 @default.
- W1974317938 cites W2017602067 @default.
- W1974317938 cites W2018046547 @default.
- W1974317938 cites W2020318124 @default.
- W1974317938 cites W2021789454 @default.
- W1974317938 cites W2025899738 @default.
- W1974317938 cites W2026494412 @default.
- W1974317938 cites W2027288287 @default.
- W1974317938 cites W2029588290 @default.
- W1974317938 cites W2030341216 @default.
- W1974317938 cites W2031349317 @default.
- W1974317938 cites W2031560484 @default.
- W1974317938 cites W2031636454 @default.
- W1974317938 cites W2031704616 @default.
- W1974317938 cites W2032462798 @default.
- W1974317938 cites W2033141337 @default.
- W1974317938 cites W2033159339 @default.
- W1974317938 cites W2035153986 @default.
- W1974317938 cites W2035869940 @default.