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• W1974327162 startingPage "2602" @default.
• W1974327162 abstract "The LIM homeodomain (LIM-HD) protein Apterous (Ap) and its cofactor DLDB/CHIP control dorso- ventral (D/V) patterning and growth of Drosophila wing. To investigate the molecular mechanisms of Ap/CHIP function we altered their relative levels of expression and generated mutants in the LIM1, LIM2 and HD domains of Ap, as well as in the LIM-interacting and self-association domains of CHIP. Using in vitro and in vivo assays we found that: (i) the levels of CHIP relative to Ap control D/V patterning; (ii) the LIM1 and LIM2 domains differ in their contributions to Ap function; (iii) Ap HD mutations cause weak dominant negative effects; (iv) overexpression of ChipDeltaSAD mutants mimics Ap lack-of-function, and this dominant negative phenotype is caused by titration of Ap because it can be rescued by adding extra Ap; and (v) overexpression of ChipDeltaLID mutants also causes an Ap lack-of-function phenotype, but it cannot be rescued by extra Ap. These results support the model that the Ap-CHIP active complex in vivo is a tetramer." @default.
• W1974327162 created "2016-06-24" @default.
• W1974327162 creator A5010385306 @default.
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• W1974327162 date "2000-06-01" @default.
• W1974327162 modified "2023-09-30" @default.
• W1974327162 title "The level of DLDB/CHIP controls the activity of the LIM homeodomain protein Apterous: evidence for a functional tetramer complex in vivo" @default.
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• W1974327162 doi "https://doi.org/10.1093/emboj/19.11.2602" @default.
• W1974327162 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/212760" @default.
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