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- W1974332480 endingPage "e1004200" @default.
- W1974332480 startingPage "e1004200" @default.
- W1974332480 abstract "Microsporidia comprise a phylum of over 1400 species of obligate intracellular pathogens that can infect almost all animals, but little is known about the host response to these parasites. Here we use the whole-animal host C. elegans to show an in vivo role for ubiquitin-mediated response to the microsporidian species Nematocida parisii, as well to the Orsay virus, another natural intracellular pathogen of C. elegans. We analyze gene expression of C. elegans in response to N. parisii, and find that it is similar to response to viral infection. Notably, we find an upregulation of SCF ubiquitin ligase components, such as the cullin ortholog cul-6, which we show is important for ubiquitin targeting of N. parisii cells in the intestine. We show that ubiquitylation components, the proteasome, and the autophagy pathway are all important for defense against N. parisii infection. We also find that SCF ligase components like cul-6 promote defense against viral infection, where they have a more robust role than against N. parisii infection. This difference may be due to suppression of the host ubiquitylation system by N. parisii: when N. parisii is crippled by anti-microsporidia drugs, the host can more effectively target pathogen cells for ubiquitylation. Intriguingly, inhibition of the ubiquitin-proteasome system (UPS) increases expression of infection-upregulated SCF ligase components, indicating that a trigger for transcriptional response to intracellular infection by N. parisii and virus may be perturbation of the UPS. Altogether, our results demonstrate an in vivo role for ubiquitin-mediated defense against microsporidian and viral infections in C. elegans." @default.
- W1974332480 created "2016-06-24" @default.
- W1974332480 creator A5009421399 @default.
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- W1974332480 creator A5035539572 @default.
- W1974332480 creator A5048465576 @default.
- W1974332480 creator A5050085152 @default.
- W1974332480 creator A5051396432 @default.
- W1974332480 creator A5070261986 @default.
- W1974332480 date "2014-06-19" @default.
- W1974332480 modified "2023-09-30" @default.
- W1974332480 title "Ubiquitin-Mediated Response to Microsporidia and Virus Infection in C. elegans" @default.
- W1974332480 cites W1739549593 @default.
- W1974332480 cites W1861728615 @default.
- W1974332480 cites W1937721715 @default.
- W1974332480 cites W1944127002 @default.
- W1974332480 cites W1963708619 @default.
- W1974332480 cites W1963844049 @default.
- W1974332480 cites W1964895626 @default.
- W1974332480 cites W1974661145 @default.
- W1974332480 cites W1975030465 @default.
- W1974332480 cites W1981899072 @default.
- W1974332480 cites W1981980855 @default.
- W1974332480 cites W1982328089 @default.
- W1974332480 cites W1986172762 @default.
- W1974332480 cites W1991533918 @default.
- W1974332480 cites W1994305081 @default.
- W1974332480 cites W1995700909 @default.
- W1974332480 cites W1999574084 @default.
- W1974332480 cites W2000444249 @default.
- W1974332480 cites W2003343630 @default.
- W1974332480 cites W2010057180 @default.
- W1974332480 cites W2010465475 @default.
- W1974332480 cites W2012104592 @default.
- W1974332480 cites W2016962320 @default.
- W1974332480 cites W2018652833 @default.
- W1974332480 cites W2019525085 @default.
- W1974332480 cites W2020639485 @default.
- W1974332480 cites W2023728126 @default.
- W1974332480 cites W2025130864 @default.
- W1974332480 cites W2026086705 @default.
- W1974332480 cites W2026932718 @default.
- W1974332480 cites W2027495004 @default.
- W1974332480 cites W2027600761 @default.
- W1974332480 cites W2030764530 @default.
- W1974332480 cites W2031516834 @default.
- W1974332480 cites W2036931975 @default.
- W1974332480 cites W2037636784 @default.
- W1974332480 cites W2039559526 @default.
- W1974332480 cites W2042718605 @default.
- W1974332480 cites W2044083819 @default.
- W1974332480 cites W2048705639 @default.
- W1974332480 cites W2049382834 @default.
- W1974332480 cites W2050657920 @default.
- W1974332480 cites W2051252016 @default.
- W1974332480 cites W2053233481 @default.
- W1974332480 cites W2055651636 @default.
- W1974332480 cites W2058422567 @default.
- W1974332480 cites W2066275867 @default.
- W1974332480 cites W2066727453 @default.
- W1974332480 cites W2069960805 @default.
- W1974332480 cites W2070137528 @default.
- W1974332480 cites W2072393395 @default.
- W1974332480 cites W2073435376 @default.
- W1974332480 cites W2080101395 @default.
- W1974332480 cites W2084630938 @default.
- W1974332480 cites W2090738979 @default.
- W1974332480 cites W2097337885 @default.
- W1974332480 cites W2098727368 @default.
- W1974332480 cites W2101070475 @default.
- W1974332480 cites W2101662471 @default.
- W1974332480 cites W2104818214 @default.
- W1974332480 cites W2106195012 @default.
- W1974332480 cites W2106362229 @default.
- W1974332480 cites W2107257265 @default.
- W1974332480 cites W2107810840 @default.
- W1974332480 cites W2107996007 @default.
- W1974332480 cites W2108244474 @default.
- W1974332480 cites W2111770156 @default.
- W1974332480 cites W2112221859 @default.
- W1974332480 cites W2113636792 @default.
- W1974332480 cites W2114104545 @default.
- W1974332480 cites W2123027148 @default.
- W1974332480 cites W2124985265 @default.
- W1974332480 cites W2125357643 @default.
- W1974332480 cites W2126763121 @default.
- W1974332480 cites W2130410032 @default.
- W1974332480 cites W2133465414 @default.
- W1974332480 cites W2134138119 @default.
- W1974332480 cites W2135574023 @default.
- W1974332480 cites W2137173138 @default.
- W1974332480 cites W2137586633 @default.
- W1974332480 cites W2138608045 @default.
- W1974332480 cites W2140534922 @default.
- W1974332480 cites W2142716822 @default.
- W1974332480 cites W2143852617 @default.
- W1974332480 cites W2146253911 @default.