FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1974333703> ?p ?o ?g. }

• W1974333703 abstract "Extracted ion chromatogram (EIC) extraction and chromatographic peak detection are two important processing procedures in liquid chromatography/mass spectrometry (LC/MS)-based metabolomics data analysis. Most commonly, the LC/MS technique employs electrospray ionization as the ionization method. The EICs from LC/MS data are often noisy and contain high background signals. Furthermore, the chromatographic peak quality varies with respect to its location in the chromatogram and most peaks have zigzag shapes. Therefore, there is a critical need to develop effective metrics for quality evaluation of EICs and chromatographic peaks in LC/MS based metabolomics data analysis.We investigated a comprehensive set of potential quality evaluation metrics for extracted EICs and detected chromatographic peaks. Specifically, for EIC quality evaluation, we analyzed the mass chromatographic quality index (MCQ index) and propose a novel quality evaluation metric, the EIC-related global zigzag index, which is based on an EIC's first order derivatives. For chromatographic peak quality evaluation, we analyzed and compared six metrics: sharpness, Gaussian similarity, signal-to-noise ratio, peak significance level, triangle peak area similarity ratio and the local peak-related local zigzag index.Although the MCQ index is suited for selecting and aligning analyte components, it cannot fairly evaluate EICs with high background signals or those containing only a single peak. Our proposed EIC related global zigzag index is robust enough to evaluate EIC qualities in both scenarios. Of the six peak quality evaluation metrics, the sharpness, peak significance level, and zigzag index outperform the others due to the zigzag nature of LC/MS chromatographic peaks. Furthermore, using several peak quality metrics in combination is more efficient than individual metrics in peak quality evaluation." @default.
• W1974333703 created "2016-06-24" @default.
• W1974333703 creator A5025380264 @default.
• W1974333703 creator A5069783573 @default.
• W1974333703 date "2014-10-21" @default.
• W1974333703 modified "2023-10-09" @default.
• W1974333703 title "Quality evaluation of extracted ion chromatograms and chromatographic peaks in liquid chromatography/mass spectrometry-based metabolomics data" @default.
• W1974333703 cites W1964010911 @default.
• W1974333703 cites W1971606140 @default.
• W1974333703 cites W1995543670 @default.
• W1974333703 cites W2017979364 @default.
• W1974333703 cites W2024592025 @default.
• W1974333703 cites W2024976223 @default.
• W1974333703 cites W2029785411 @default.
• W1974333703 cites W2037188908 @default.
• W1974333703 cites W2043451976 @default.
• W1974333703 cites W2065021234 @default.
• W1974333703 cites W2072929489 @default.
• W1974333703 cites W2096975486 @default.
• W1974333703 cites W2100200067 @default.
• W1974333703 cites W2105084411 @default.
• W1974333703 cites W2114754207 @default.
• W1974333703 cites W2168130065 @default.
• W1974333703 cites W2168590651 @default.
• W1974333703 cites W2313110944 @default.
• W1974333703 cites W2317969237 @default.
• W1974333703 doi "https://doi.org/10.1186/1471-2105-15-s11-s5" @default.
• W1974333703 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4251050" @default.
• W1974333703 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25350128" @default.
• W1974333703 hasPublicationYear "2014" @default.
• W1974333703 type Work @default.
• W1974333703 sameAs 1974333703 @default.
• W1974333703 citedByCount "22" @default.
• W1974333703 countsByYear W19743337032014 @default.
• W1974333703 countsByYear W19743337032016 @default.
• W1974333703 countsByYear W19743337032017 @default.
• W1974333703 countsByYear W19743337032018 @default.
• W1974333703 countsByYear W19743337032019 @default.
• W1974333703 countsByYear W19743337032020 @default.
• W1974333703 countsByYear W19743337032021 @default.
• W1974333703 countsByYear W19743337032022 @default.
• W1974333703 countsByYear W19743337032023 @default.
• W1974333703 crossrefType "journal-article" @default.
• W1974333703 hasAuthorship W1974333703A5025380264 @default.
• W1974333703 hasAuthorship W1974333703A5069783573 @default.
• W1974333703 hasBestOaLocation W19743337031 @default.
• W1974333703 hasConcept C103278499 @default.
• W1974333703 hasConcept C113196181 @default.
• W1974333703 hasConcept C115961682 @default.
• W1974333703 hasConcept C153180895 @default.
• W1974333703 hasConcept C154945302 @default.
• W1974333703 hasConcept C162324750 @default.
• W1974333703 hasConcept C162356407 @default.
• W1974333703 hasConcept C176217482 @default.
• W1974333703 hasConcept C185592680 @default.
• W1974333703 hasConcept C192271897 @default.
• W1974333703 hasConcept C203519979 @default.
• W1974333703 hasConcept C21547014 @default.
• W1974333703 hasConcept C21565614 @default.
• W1974333703 hasConcept C2524010 @default.
• W1974333703 hasConcept C33923547 @default.
• W1974333703 hasConcept C40684141 @default.
• W1974333703 hasConcept C41008148 @default.
• W1974333703 hasConcept C43617362 @default.
• W1974333703 hasConceptScore W1974333703C103278499 @default.
• W1974333703 hasConceptScore W1974333703C113196181 @default.
• W1974333703 hasConceptScore W1974333703C115961682 @default.
• W1974333703 hasConceptScore W1974333703C153180895 @default.
• W1974333703 hasConceptScore W1974333703C154945302 @default.
• W1974333703 hasConceptScore W1974333703C162324750 @default.
• W1974333703 hasConceptScore W1974333703C162356407 @default.
• W1974333703 hasConceptScore W1974333703C176217482 @default.
• W1974333703 hasConceptScore W1974333703C185592680 @default.
• W1974333703 hasConceptScore W1974333703C192271897 @default.
• W1974333703 hasConceptScore W1974333703C203519979 @default.
• W1974333703 hasConceptScore W1974333703C21547014 @default.
• W1974333703 hasConceptScore W1974333703C21565614 @default.
• W1974333703 hasConceptScore W1974333703C2524010 @default.
• W1974333703 hasConceptScore W1974333703C33923547 @default.
• W1974333703 hasConceptScore W1974333703C40684141 @default.
• W1974333703 hasConceptScore W1974333703C41008148 @default.
• W1974333703 hasConceptScore W1974333703C43617362 @default.
• W1974333703 hasIssue "S11" @default.
• W1974333703 hasLocation W19743337031 @default.
• W1974333703 hasLocation W19743337032 @default.
• W1974333703 hasLocation W19743337033 @default.
• W1974333703 hasLocation W19743337034 @default.
• W1974333703 hasOpenAccess W1974333703 @default.
• W1974333703 hasPrimaryLocation W19743337031 @default.
• W1974333703 hasRelatedWork W1968153730 @default.
• W1974333703 hasRelatedWork W2003174742 @default.
• W1974333703 hasRelatedWork W2042359715 @default.
• W1974333703 hasRelatedWork W2050011283 @default.
• W1974333703 hasRelatedWork W2162212413 @default.
• W1974333703 hasRelatedWork W2162864452 @default.
• W1974333703 hasRelatedWork W2164884627 @default.
• W1974333703 hasRelatedWork W274350598 @default.
• W1974333703 hasRelatedWork W2914152172 @default.
• W1974333703 hasRelatedWork W3017168873 @default.
• W1974333703 hasVolume "15" @default.

• next