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• W1974346374 endingPage "4591" @default.
• W1974346374 startingPage "4581" @default.
• W1974346374 abstract "The Aplysia feeding system with its high degree of plasticity and well characterized neuronal circuitry is well suited for investigations of memory formation. We used an operant paradigm, learning that food is inedible (LFI), to investigate the signaling pathways underlying intermediate-term memory (ITM) in Aplysia. During a single massed training session, the animal associates a specific seaweed with the failure to swallow, generating short-term (30 min) and long-term (24 h) memory. We investigated whether the same training protocol induced the formation of ITM. We found that massed LFI training resulted in temporally distinct protein synthesis-dependent memory evident 4-6 h after training. Through in vivo experiments, we determined that the formation of ITM required protein kinase A, protein kinase C, and MAPK. Moreover, the maintenance of ITM required PKA, PKM Apl III, and MAPK because inhibition of any of these kinases after training or before testing blocked the expression of memory. In contrast, additional experiments determined that the maintenance of long-term memory appeared independent of PKM Apl III. Using Western blotting, we found that sustained MAPK phosphorylation was dependent upon protein synthesis, but not PKA or PKC activity. Thus, massed training-induced intermediate-term operant memory requires protein synthesis as well as persistent or sustained kinase signaling for PKA, PKC, and MAPK. While short-, intermediate-, and long-term memory are induced by the same training protocol, considerable differences exist in both the combination and timing of signaling cascades that induce the formation and maintenance of these temporally distinct memories." @default.
• W1974346374 created "2016-06-24" @default.
• W1974346374 creator A5023337176 @default.
• W1974346374 creator A5037186009 @default.
• W1974346374 creator A5050886015 @default.
• W1974346374 creator A5066403083 @default.
• W1974346374 creator A5087204863 @default.
• W1974346374 date "2012-03-28" @default.
• W1974346374 modified "2023-10-16" @default.
• W1974346374 title "Massed Training-Induced Intermediate-Term Operant Memory in<i>Aplysia</i>Requires Protein Synthesis and Multiple Persistent Kinase Cascades" @default.
• W1974346374 cites W108463644 @default.
• W1974346374 cites W1550519555 @default.
• W1974346374 cites W1555886595 @default.
• W1974346374 cites W1571281589 @default.
• W1974346374 cites W1578803168 @default.
• W1974346374 cites W1882457987 @default.
• W1974346374 cites W1917382590 @default.
• W1974346374 cites W1974192130 @default.
• W1974346374 cites W1975711591 @default.
• W1974346374 cites W1979055157 @default.
• W1974346374 cites W1979412265 @default.
• W1974346374 cites W1980089349 @default.
• W1974346374 cites W1985927272 @default.
• W1974346374 cites W1987030209 @default.
• W1974346374 cites W1988259888 @default.
• W1974346374 cites W1990136143 @default.
• W1974346374 cites W1990479511 @default.
• W1974346374 cites W1990486199 @default.
• W1974346374 cites W1991355251 @default.
• W1974346374 cites W1997973656 @default.
• W1974346374 cites W1998696781 @default.
• W1974346374 cites W2003000287 @default.
• W1974346374 cites W2009514858 @default.
• W1974346374 cites W2010231891 @default.
• W1974346374 cites W2014050156 @default.
• W1974346374 cites W2019100219 @default.
• W1974346374 cites W2020520478 @default.
• W1974346374 cites W2029085929 @default.
• W1974346374 cites W2033255033 @default.
• W1974346374 cites W2036289743 @default.
• W1974346374 cites W2037753329 @default.
• W1974346374 cites W2039891360 @default.
• W1974346374 cites W2040263305 @default.
• W1974346374 cites W2046656964 @default.
• W1974346374 cites W2050970191 @default.
• W1974346374 cites W2052750950 @default.
• W1974346374 cites W2058851330 @default.
• W1974346374 cites W2060929421 @default.
• W1974346374 cites W2066592391 @default.
• W1974346374 cites W2067792927 @default.
• W1974346374 cites W2069705491 @default.
• W1974346374 cites W2072622170 @default.
• W1974346374 cites W2074113083 @default.
• W1974346374 cites W2076800034 @default.
• W1974346374 cites W2081863440 @default.
• W1974346374 cites W2081984633 @default.
• W1974346374 cites W2083277982 @default.
• W1974346374 cites W2084252221 @default.
• W1974346374 cites W2085280043 @default.
• W1974346374 cites W2086559167 @default.
• W1974346374 cites W2086608732 @default.
• W1974346374 cites W2087973535 @default.
• W1974346374 cites W2091339773 @default.
• W1974346374 cites W2092893243 @default.
• W1974346374 cites W2101626807 @default.
• W1974346374 cites W2109552347 @default.
• W1974346374 cites W2110137543 @default.
• W1974346374 cites W2110241784 @default.
• W1974346374 cites W2111342014 @default.
• W1974346374 cites W2111611651 @default.
• W1974346374 cites W2111735128 @default.
• W1974346374 cites W2113594310 @default.
• W1974346374 cites W2115021882 @default.
• W1974346374 cites W2115089079 @default.
• W1974346374 cites W2120149263 @default.
• W1974346374 cites W2127620502 @default.
• W1974346374 cites W2133083344 @default.
• W1974346374 cites W2138595433 @default.
• W1974346374 cites W2139272388 @default.
• W1974346374 cites W2141014036 @default.
• W1974346374 cites W2148348802 @default.
• W1974346374 cites W2148842967 @default.
• W1974346374 cites W2149017623 @default.
• W1974346374 cites W2153756971 @default.
• W1974346374 cites W2154414197 @default.
• W1974346374 cites W2157485339 @default.
• W1974346374 cites W2157805785 @default.
• W1974346374 cites W2160180740 @default.
• W1974346374 cites W2163662039 @default.
• W1974346374 cites W2175525622 @default.
• W1974346374 cites W2316934743 @default.
• W1974346374 cites W2342247332 @default.
• W1974346374 cites W2406027999 @default.
• W1974346374 cites W309050847 @default.
• W1974346374 cites W4244864219 @default.
• W1974346374 cites W4312861507 @default.
• W1974346374 cites W4323284009 @default.
• W1974346374 cites W5462926 @default.

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