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• W1974362693 endingPage "379" @default.
• W1974362693 startingPage "359" @default.
• W1974362693 abstract "As we learn more about the biology of the Toll-like receptors (TLRs), a wide range of molecules that can activate this fascinating family of pattern recognition receptors emerges. In addition to conserved pathogenic components, endogenous danger signals created upon tissue damage are also sensed by TLRs. Detection of these types of stimuli results in TLR mediated inflammation that is vital to fight pathogenic invasion and drive tissue repair. Aberrant activation of TLRs by pathogenic and endogenous ligands has also been linked with the pathogenesis of an increasing number of infectious and autoimmune diseases, respectively. Most recently, allergen activation of TLRs has also been described, creating a third broad class of TLR stimulus that has helped to shed light on the pathogenesis of allergic disease. To date, microbial activation of TLRs remains best characterized. Each member of the TLR family senses a specific subset of pathogenic ligands, pathogen associated molecular patterns (PAMPS), and a wealth of structural and biochemical data continues to reveal the molecular mechanisms of TLR activation by PAMPs, and to demonstrate how receptor specificity is achieved. In contrast, the mechanisms by which endogenous molecules and allergens activate TLRs remain much more mysterious. Here, we provide an overview of our current knowledge of how very diverse stimuli activate the same TLRs and the structural basis of these modes of immunity." @default.
• W1974362693 created "2016-06-24" @default.
• W1974362693 creator A5002720012 @default.
• W1974362693 creator A5047516847 @default.
• W1974362693 creator A5051400574 @default.
• W1974362693 creator A5065724319 @default.
• W1974362693 creator A5091304244 @default.
• W1974362693 date "2015-04-10" @default.
• W1974362693 modified "2023-09-27" @default.
• W1974362693 title "Advances in Toll-like receptor biology: Modes of activation by diverse stimuli" @default.
• W1974362693 cites W1494706121 @default.
• W1974362693 cites W1518477539 @default.
• W1974362693 cites W1520365933 @default.
• W1974362693 cites W1577752952 @default.
• W1974362693 cites W1598189106 @default.
• W1974362693 cites W1612531854 @default.
• W1974362693 cites W1623115463 @default.
• W1974362693 cites W1760966156 @default.
• W1974362693 cites W1889494500 @default.
• W1974362693 cites W1964793822 @default.
• W1974362693 cites W1968152808 @default.
• W1974362693 cites W1968712129 @default.
• W1974362693 cites W1969072247 @default.
• W1974362693 cites W1970200599 @default.
• W1974362693 cites W1970951405 @default.
• W1974362693 cites W1972286147 @default.
• W1974362693 cites W1972776583 @default.
• W1974362693 cites W1976711591 @default.
• W1974362693 cites W1977968924 @default.
• W1974362693 cites W1978318965 @default.
• W1974362693 cites W1978962348 @default.
• W1974362693 cites W1980768668 @default.
• W1974362693 cites W1981645153 @default.
• W1974362693 cites W1982657650 @default.
• W1974362693 cites W1982718713 @default.
• W1974362693 cites W1983419107 @default.
• W1974362693 cites W1983875399 @default.
• W1974362693 cites W1986176487 @default.
• W1974362693 cites W1986178107 @default.
• W1974362693 cites W1986706100 @default.
• W1974362693 cites W1986808693 @default.
• W1974362693 cites W1987383242 @default.
• W1974362693 cites W1987562115 @default.
• W1974362693 cites W1988673189 @default.
• W1974362693 cites W1989978175 @default.
• W1974362693 cites W1990142540 @default.
• W1974362693 cites W1990872903 @default.
• W1974362693 cites W1991412427 @default.
• W1974362693 cites W1991731944 @default.
• W1974362693 cites W1991872527 @default.
• W1974362693 cites W1994391392 @default.
• W1974362693 cites W1995948381 @default.
• W1974362693 cites W1996671942 @default.
• W1974362693 cites W1997269917 @default.
• W1974362693 cites W1997344803 @default.
• W1974362693 cites W1997450131 @default.
• W1974362693 cites W1997977259 @default.
• W1974362693 cites W1998612008 @default.
• W1974362693 cites W1998895223 @default.
• W1974362693 cites W1999546563 @default.
• W1974362693 cites W2000121122 @default.
• W1974362693 cites W2000787206 @default.
• W1974362693 cites W2001244523 @default.
• W1974362693 cites W2001757395 @default.
• W1974362693 cites W2001769615 @default.
• W1974362693 cites W2001904356 @default.
• W1974362693 cites W2003782660 @default.
• W1974362693 cites W2006076437 @default.
• W1974362693 cites W2007001334 @default.
• W1974362693 cites W2007080727 @default.
• W1974362693 cites W2007783705 @default.
• W1974362693 cites W2009103286 @default.
• W1974362693 cites W2009298572 @default.
• W1974362693 cites W2009495759 @default.
• W1974362693 cites W2011607230 @default.
• W1974362693 cites W2013469022 @default.
• W1974362693 cites W2016005410 @default.
• W1974362693 cites W2016255028 @default.
• W1974362693 cites W2018172685 @default.
• W1974362693 cites W2019587275 @default.
• W1974362693 cites W2021100840 @default.
• W1974362693 cites W2021656891 @default.
• W1974362693 cites W2022590956 @default.
• W1974362693 cites W2022680502 @default.
• W1974362693 cites W2023713176 @default.
• W1974362693 cites W2023718084 @default.
• W1974362693 cites W2024694557 @default.
• W1974362693 cites W2026550755 @default.
• W1974362693 cites W2026884617 @default.
• W1974362693 cites W2027166393 @default.
• W1974362693 cites W2027689057 @default.
• W1974362693 cites W2028320377 @default.
• W1974362693 cites W2028491403 @default.
• W1974362693 cites W2029339804 @default.
• W1974362693 cites W2031309074 @default.
• W1974362693 cites W2032056947 @default.
• W1974362693 cites W2032704370 @default.
• W1974362693 cites W2032724693 @default.

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