FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1974370090> ?p ?o ?g. }

• W1974370090 endingPage "288" @default.
• W1974370090 startingPage "281" @default.
• W1974370090 abstract "Background While stressful life events can enhance the risk of mental disorders, positive social interactions can propagate good mental health and normal behavioral routines. Still, the neural systems that promote these benefits are undetermined. Oxytocin is a hormone involved in social behavior and stress; thus, we focus on the impact that social buffering has on the stress response and the governing effects of oxytocin. Methods Female prairie voles (Microtus ochrogaster) were exposed to 1 hour immobilization stress and then recovered alone or with their male partner to characterize the effect of social contact on the behavioral, physiological, and neuroendocrine stress response. In addition, we treated immobilized female voles recovering alone with oxytocin or vehicle and female voles recovering with their male partner with a selective oxytocin receptor antagonist or vehicle. Group sizes varied from 6 to 8 voles (N = 98 total). Results We found that 1 hour immobilization increased anxiety-like behaviors and circulating levels of corticosterone, a stress hormone, in female prairie voles recovering alone but not the female prairie voles recovering with their male partner. This social buffering by the male partner on biobehavioral responses to stress was accompanied by increased oxytocin release in the paraventricular nucleus of the hypothalamus. Intra-paraventricular nucleus oxytocin injections reduced behavioral and corticosterone responses to immobilization, whereas injections of an oxytocin receptor antagonist blocked the effects of the social buffering. Conclusions Together, our data demonstrate that paraventricular nucleus oxytocin mediates the social buffering effects on the stress response and thus may be a target for treatment of stress-related disorders. While stressful life events can enhance the risk of mental disorders, positive social interactions can propagate good mental health and normal behavioral routines. Still, the neural systems that promote these benefits are undetermined. Oxytocin is a hormone involved in social behavior and stress; thus, we focus on the impact that social buffering has on the stress response and the governing effects of oxytocin. Female prairie voles (Microtus ochrogaster) were exposed to 1 hour immobilization stress and then recovered alone or with their male partner to characterize the effect of social contact on the behavioral, physiological, and neuroendocrine stress response. In addition, we treated immobilized female voles recovering alone with oxytocin or vehicle and female voles recovering with their male partner with a selective oxytocin receptor antagonist or vehicle. Group sizes varied from 6 to 8 voles (N = 98 total). We found that 1 hour immobilization increased anxiety-like behaviors and circulating levels of corticosterone, a stress hormone, in female prairie voles recovering alone but not the female prairie voles recovering with their male partner. This social buffering by the male partner on biobehavioral responses to stress was accompanied by increased oxytocin release in the paraventricular nucleus of the hypothalamus. Intra-paraventricular nucleus oxytocin injections reduced behavioral and corticosterone responses to immobilization, whereas injections of an oxytocin receptor antagonist blocked the effects of the social buffering. Together, our data demonstrate that paraventricular nucleus oxytocin mediates the social buffering effects on the stress response and thus may be a target for treatment of stress-related disorders." @default.
• W1974370090 created "2016-06-24" @default.
• W1974370090 creator A5008934143 @default.
• W1974370090 creator A5039018479 @default.
• W1974370090 date "2014-08-01" @default.
• W1974370090 modified "2023-10-18" @default.
• W1974370090 title "Hypothalamic Oxytocin Mediates Social Buffering of the Stress Response" @default.
• W1974370090 cites W1870629785 @default.
• W1974370090 cites W1882504357 @default.
• W1974370090 cites W1969767756 @default.
• W1974370090 cites W1970239899 @default.
• W1974370090 cites W1977529793 @default.
• W1974370090 cites W1981979601 @default.
• W1974370090 cites W1990099840 @default.
• W1974370090 cites W1992034559 @default.
• W1974370090 cites W1997126400 @default.
• W1974370090 cites W1997235585 @default.
• W1974370090 cites W2003759064 @default.
• W1974370090 cites W2010883247 @default.
• W1974370090 cites W2017323063 @default.
• W1974370090 cites W2019584232 @default.
• W1974370090 cites W2022429467 @default.
• W1974370090 cites W2023434748 @default.
• W1974370090 cites W202927640 @default.
• W1974370090 cites W2037242891 @default.
• W1974370090 cites W2037352620 @default.
• W1974370090 cites W2040558085 @default.
• W1974370090 cites W2040669388 @default.
• W1974370090 cites W2048245983 @default.
• W1974370090 cites W2055461003 @default.
• W1974370090 cites W2055761781 @default.
• W1974370090 cites W2061566303 @default.
• W1974370090 cites W2062089118 @default.
• W1974370090 cites W2074434042 @default.
• W1974370090 cites W2078195699 @default.
• W1974370090 cites W2080133965 @default.
• W1974370090 cites W2081567401 @default.
• W1974370090 cites W2085847387 @default.
• W1974370090 cites W2086935212 @default.
• W1974370090 cites W2090689542 @default.
• W1974370090 cites W2090886158 @default.
• W1974370090 cites W2091036510 @default.
• W1974370090 cites W2094195036 @default.
• W1974370090 cites W2097571882 @default.
• W1974370090 cites W2110602106 @default.
• W1974370090 cites W2117679221 @default.
• W1974370090 cites W2123936744 @default.
• W1974370090 cites W2137975206 @default.
• W1974370090 cites W2142877367 @default.
• W1974370090 cites W2143187555 @default.
• W1974370090 cites W2155351060 @default.
• W1974370090 cites W2168161193 @default.
• W1974370090 cites W65726938 @default.
• W1974370090 doi "https://doi.org/10.1016/j.biopsych.2013.09.017" @default.
• W1974370090 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3969451" @default.
• W1974370090 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24183103" @default.
• W1974370090 hasPublicationYear "2014" @default.
• W1974370090 type Work @default.
• W1974370090 sameAs 1974370090 @default.
• W1974370090 citedByCount "257" @default.
• W1974370090 countsByYear W19743700902014 @default.
• W1974370090 countsByYear W19743700902015 @default.
• W1974370090 countsByYear W19743700902016 @default.
• W1974370090 countsByYear W19743700902017 @default.
• W1974370090 countsByYear W19743700902018 @default.
• W1974370090 countsByYear W19743700902019 @default.
• W1974370090 countsByYear W19743700902020 @default.
• W1974370090 countsByYear W19743700902021 @default.
• W1974370090 countsByYear W19743700902022 @default.
• W1974370090 countsByYear W19743700902023 @default.
• W1974370090 crossrefType "journal-article" @default.
• W1974370090 hasAuthorship W1974370090A5008934143 @default.
• W1974370090 hasAuthorship W1974370090A5039018479 @default.
• W1974370090 hasBestOaLocation W19743700902 @default.
• W1974370090 hasConcept C118303440 @default.
• W1974370090 hasConcept C126322002 @default.
• W1974370090 hasConcept C134018914 @default.
• W1974370090 hasConcept C15744967 @default.
• W1974370090 hasConcept C16634123 @default.
• W1974370090 hasConcept C169760540 @default.
• W1974370090 hasConcept C170493617 @default.
• W1974370090 hasConcept C181612422 @default.
• W1974370090 hasConcept C18903297 @default.
• W1974370090 hasConcept C2775855782 @default.
• W1974370090 hasConcept C2776176026 @default.
• W1974370090 hasConcept C2776885963 @default.
• W1974370090 hasConcept C2777003273 @default.
• W1974370090 hasConcept C2780138302 @default.
• W1974370090 hasConcept C2780352252 @default.
• W1974370090 hasConcept C2780817734 @default.
• W1974370090 hasConcept C71315377 @default.
• W1974370090 hasConcept C71924100 @default.
• W1974370090 hasConcept C86803240 @default.
• W1974370090 hasConceptScore W1974370090C118303440 @default.
• W1974370090 hasConceptScore W1974370090C126322002 @default.
• W1974370090 hasConceptScore W1974370090C134018914 @default.
• W1974370090 hasConceptScore W1974370090C15744967 @default.
• W1974370090 hasConceptScore W1974370090C16634123 @default.

• next