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• W1974373472 abstract "The mechanisms driving bone marrow stem cell mobilization are poorly understood. A recent murine study found that circulating bone marrow-derived osteoprogenitor cells (MOPCs) were recruited to the site of recombinant human bone morphogenetic protein-2 (BMP-2)-induced bone formation. Stromal cell-derived factor-1α (SDF-1α) and its cellular receptor CXCR4 have been shown to mediate the homing of stem cells to injured tissues. We hypothesized that chemokines, such as SDF-1, are also involved with mobilization of bone marrow cells. The CD45(-) fraction is a major source of MOPCs. In this report we determined that the addition of BMP-2 or SDF-1 to collagen implants increased the number of MOPCs in the peripheral blood. BMP-2-induced mobilization was blocked by CXCR4 antibody, confirming the role of SDF-1 in mobilization. We determined for the first time that addition of SDF-1 to implants containing BMP-2 enhances mobilization, homing of MOPCs to the implant, and ectopic bone formation induced by suboptimal BMP-2 doses. These results suggest that SDF-1 increases the number of osteoprogenitor cells that are mobilized from the bone marrow and then home to the implant. Thus, addition of SDF-1 to BMP-2 may improve the efficiency of BMPs in vivo, making their routine use for orthopaedic applications more affordable and available to more patients." @default.
• W1974373472 created "2016-06-24" @default.
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• W1974373472 date "2011-02-01" @default.
• W1974373472 modified "2023-10-01" @default.
• W1974373472 title "Stromal Cell-Derived Factor-1 Potentiates Bone Morphogenetic Protein-2 Induced Bone Formation" @default.
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• W1974373472 doi "https://doi.org/10.1089/ten.tea.2010.0168" @default.
• W1974373472 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21043834" @default.
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