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- W1974393133 abstract "We describe studies on human breast cancer in which it is shown that specific growth factors (IGF-I, TGFα, PDGF) are secreted by human breast cancer cells and likely to be involved in tumor growth and progression. These activities are regulated by estradiol in hormone-dependent breast cancer and secreted constitutively by hormone-independent cells. These growth factor activities can induce the growth of hormone-dependent cells in vivo in athymic nude mice. Hormone-dependent breast cancer cells also secrete TGFβ, a growth-inhibitory substance, when treated with antiestrogens. TGFβ functions as a negative autocrine growth regulator and is responsible for some of the growth-inhibitory effects of antiestrogens." @default.
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- W1974393133 date "1987-09-01" @default.
- W1974393133 modified "2023-10-17" @default.
- W1974393133 title "Growth regulation of human breast carcinoma occurs through regulated growth factor secretion" @default.
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- W1974393133 doi "https://doi.org/10.1002/jcb.240350102" @default.
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