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• W1974414596 abstract "The synthesis of a series of novel 2-(aminoalkyl)-2,3,3a,8-tetrahydrodibenzo[c,f]isoxazolo[2,3-a]azepine derivatives as well as their 5-HT2A/2C and H1 receptor binding affinities are described. The in vivo activity as potential anxiolytics of the synthesised compounds was measured in a mCPP challenge test. One of the compounds, 2a, proved to be a potent 5-HT2A/2C receptor antagonist showing as well oral activity and therefore could be considered as a potential anxiolytic/antidepressant agent." @default.
• W1974414596 created "2016-06-24" @default.
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• W1974414596 date "2002-01-01" @default.
• W1974414596 modified "2023-10-07" @default.
• W1974414596 title "Synthesis and structure–activity relationship of 2-(aminoalkyl)-2,3,3a,8-tetrahydrodibenzo[c,f]isoxazolo[2,3-a]azepine derivatives: a novel series of 5-HT2A/2C receptor antagonists. Part 1" @default.
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• W1974414596 doi "https://doi.org/10.1016/s0960-894x(01)00721-1" @default.
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