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- W1974417779 abstract "Dysfunction in circuits linking frontal cortex and basal ganglia (BG) is strongly implicated in obsessive-compulsive disorder (OCD). On MRI studies, neuropsychiatric disorders with known BG pathology have abnormally short T2 relaxation values (a putative biomarker of elevated iron) in this region. We asked if BG T2 values are abnormal in OCD. We measured volume and T2 and T1 relaxation rates in BG of 32 adults with OCD and 33 matched controls. There were no group differences in volume or T1 values in caudate, putamen, or globus pallidus (GP). The OCD group had lower T2 values (suggesting higher iron content) in the right GP, with a trend in the same direction for the left GP. This effect was driven by patients whose OCD symptoms began from around adolescence to early adulthood. The results suggest a possible relationship between age of OCD onset and iron deposition in the basal ganglia." @default.
- W1974417779 created "2016-06-24" @default.
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- W1974417779 date "2009-12-12" @default.
- W1974417779 modified "2023-10-18" @default.
- W1974417779 title "Basal Ganglia MR Relaxometry in Obsessive-Compulsive Disorder: T2 Depends Upon Age of Symptom Onset" @default.
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- W1974417779 doi "https://doi.org/10.1007/s11682-009-9083-2" @default.
- W1974417779 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3018344" @default.
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- W1974417779 hasPublicationYear "2009" @default.
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