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• W1974424211 abstract "CD5(+) B lymphocytes have distinct functional properties compared with B lymphocytes that lack CD5. However, it remains unclear if and how the CD5 molecule modulates B lymphocyte biology and responses. Our recent studies have revealed that CD5 promotes constitutive activation of multiple signaling pathways including extracellular signal-regulated kinases (ERK1/2), phosphatidylinositol 3-kinase (PI-3K)/mammalian target of rapamycin (mTOR) and calcineurin-NFAT signaling pathways. Further, changes in cytokine production including the production of IL-10 are related to the activation of the transcription factors NFAT2 and STAT3. All in all, these studies provide a framework for understanding how CD5 impacts B lymphocyte biology and responses." @default.
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• W1974424211 date "2012-09-01" @default.
• W1974424211 modified "2023-10-05" @default.
• W1974424211 title "CD5 expression promotes multiple intracellular signaling pathways in B lymphocyte" @default.
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• W1974424211 doi "https://doi.org/10.1016/j.autrev.2012.02.007" @default.
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