Matches in SemOpenAlex for { <https://semopenalex.org/work/W1974427874> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W1974427874 endingPage "462" @default.
- W1974427874 startingPage "459" @default.
- W1974427874 abstract "Although nicotinamide administration has increased the radiosensitivity of experimental tumors, there is a scarcity of data detailing the underlying physiological mechanisms. The current study presents a method for quantifying both microregional distributions of intravascular HbO2 saturations and the presence or absence of blood flow in adjacent frozen tumor sections.Two murine tumor cell lines, KHT and SCCVII, were implanted and quick-frozen without the use of anesthetics. Nicotinamide was administered IP 1 h prior to freezing, and a fluorescent dye that preferentially stains cells adjacent to blood vessels was injected i.v. 1 min prior to freezing. To visualize the presence or absence of blood flow, six micron sections were first cut using a cryostat. The remaining frozen tumor block was then analyzed cryospectrophotometrically to determine intravascular HbO2 levels.While KHT HbO2 levels increased somewhat predictably following nicotinamide, the response in SCCVII tumors varied with distance from the tumor surface. Near the periphery, SCCVII HbO2 levels increased, but nearer the tumor center, HbO2 levels actually decreased. Perfused blood vessels were uniformly distributed throughout the tumor volume except in regions of necrosis. Even vessels containing no measurable oxygen remained perfused, as evidenced by the presence of the fluorescent marker.These results demonstrate that nicotinamide raises intravascular HbO2 saturations in both KHT and SCCVII tumors. This increase in oxygen delivery is not evenly distributed throughout the tumor volume in spite of a uniform distribution of perfused blood vessels. Blood flow in a substantial proportion of these vessels is most likely not sufficiently rapid to serve a functional purpose in terms of oxygen supply to the surrounding tumor tissue." @default.
- W1974427874 created "2016-06-24" @default.
- W1974427874 creator A5001315013 @default.
- W1974427874 creator A5014289543 @default.
- W1974427874 date "1994-06-01" @default.
- W1974427874 modified "2023-09-25" @default.
- W1974427874 title "Micro-regional mapping of HbO2 saturations and blood flow following nicotinamide administration" @default.
- W1974427874 cites W1981634775 @default.
- W1974427874 cites W2009515263 @default.
- W1974427874 cites W2016060217 @default.
- W1974427874 cites W2053084058 @default.
- W1974427874 cites W2059887025 @default.
- W1974427874 cites W2062822277 @default.
- W1974427874 cites W2080647280 @default.
- W1974427874 cites W2081586048 @default.
- W1974427874 cites W2103608368 @default.
- W1974427874 cites W2109664798 @default.
- W1974427874 cites W2117562239 @default.
- W1974427874 cites W2135974839 @default.
- W1974427874 cites W2322200077 @default.
- W1974427874 cites W2326574275 @default.
- W1974427874 cites W2473813582 @default.
- W1974427874 doi "https://doi.org/10.1016/0360-3016(94)90438-3" @default.
- W1974427874 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8005799" @default.
- W1974427874 hasPublicationYear "1994" @default.
- W1974427874 type Work @default.
- W1974427874 sameAs 1974427874 @default.
- W1974427874 citedByCount "17" @default.
- W1974427874 crossrefType "journal-article" @default.
- W1974427874 hasAuthorship W1974427874A5001315013 @default.
- W1974427874 hasAuthorship W1974427874A5014289543 @default.
- W1974427874 hasConcept C142724271 @default.
- W1974427874 hasConcept C158846371 @default.
- W1974427874 hasConcept C164705383 @default.
- W1974427874 hasConcept C181199279 @default.
- W1974427874 hasConcept C185592680 @default.
- W1974427874 hasConcept C2779728014 @default.
- W1974427874 hasConcept C2989005 @default.
- W1974427874 hasConcept C37557685 @default.
- W1974427874 hasConcept C42219234 @default.
- W1974427874 hasConcept C55493867 @default.
- W1974427874 hasConcept C71924100 @default.
- W1974427874 hasConceptScore W1974427874C142724271 @default.
- W1974427874 hasConceptScore W1974427874C158846371 @default.
- W1974427874 hasConceptScore W1974427874C164705383 @default.
- W1974427874 hasConceptScore W1974427874C181199279 @default.
- W1974427874 hasConceptScore W1974427874C185592680 @default.
- W1974427874 hasConceptScore W1974427874C2779728014 @default.
- W1974427874 hasConceptScore W1974427874C2989005 @default.
- W1974427874 hasConceptScore W1974427874C37557685 @default.
- W1974427874 hasConceptScore W1974427874C42219234 @default.
- W1974427874 hasConceptScore W1974427874C55493867 @default.
- W1974427874 hasConceptScore W1974427874C71924100 @default.
- W1974427874 hasIssue "3" @default.
- W1974427874 hasLocation W19744278741 @default.
- W1974427874 hasLocation W19744278742 @default.
- W1974427874 hasOpenAccess W1974427874 @default.
- W1974427874 hasPrimaryLocation W19744278741 @default.
- W1974427874 hasRelatedWork W1983924596 @default.
- W1974427874 hasRelatedWork W2036269063 @default.
- W1974427874 hasRelatedWork W2074261875 @default.
- W1974427874 hasRelatedWork W2113392961 @default.
- W1974427874 hasRelatedWork W2154749109 @default.
- W1974427874 hasRelatedWork W2171725007 @default.
- W1974427874 hasRelatedWork W2313295756 @default.
- W1974427874 hasRelatedWork W2318220599 @default.
- W1974427874 hasRelatedWork W2794817425 @default.
- W1974427874 hasRelatedWork W3044297310 @default.
- W1974427874 hasVolume "29" @default.
- W1974427874 isParatext "false" @default.
- W1974427874 isRetracted "false" @default.
- W1974427874 magId "1974427874" @default.
- W1974427874 workType "article" @default.