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• W1974433771 endingPage "6781" @default.
• W1974433771 startingPage "6774" @default.
• W1974433771 abstract "The formation of interstrand cross-links in nucleic acids can have a strong impact on biological function of nucleic acids; therefore, many cross-linking agents have been developed for biological applications. Despite numerous studies, there remains a need for cross-linking agents that exhibit both efficiency and selectivity. In this study, a 4-vinyl-substituted analog of thymidine (T-vinyl derivative) was designed as a new cross-linking agent, in which the vinyl group is oriented towards the Watson-Crick face to react with the amino group of an adenine base. The interstrand cross-link formed rapidly and selectively with a uridine on the RNA substrate at the site opposite to the T-vinyl derivative. A detailed analysis of cross-link formation while varying the flanking bases of the RNA substrates indicated that interstrand cross-link formation is preferential for the adenine base on the 5'-side of the opposing uridine. In the absence of a 5'-adenine, a uridine at the opposite position underwent cross-linking. The oligodeoxynucleotides probe incorporating the T-vinyl derivative efficiently formed interstrand cross-links in parallel-type triplex DNA with high selectivity for dA in the homopurine strand. The efficiency and selectivity of the T-vinyl derivative illustrate its potential use as a unique tool in biological and materials research." @default.
• W1974433771 created "2016-06-24" @default.
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• W1974433771 date "2013-06-18" @default.
• W1974433771 modified "2023-10-16" @default.
• W1974433771 title "4-vinyl-substituted pyrimidine nucleosides exhibit the efficient and selective formation of interstrand cross-links with RNA and duplex DNA" @default.
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• W1974433771 doi "https://doi.org/10.1093/nar/gkt197" @default.
• W1974433771 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3711451" @default.
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