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• W1974435880 abstract "During our research on novel, non-traditional, bicyclic β-lactams as potential inhibitors of Penicillin Binding Proteins (PBPs), we focused on the synthesis of 1,3-bridged 2-azetidinones by RCM reaction from 1,3-bis-ω-alkenoyl-3(S)-amino-2-azetidinone precursors. Submitting the precursors to RCM, we faced an unexpected problem: cyclodimerization was the preferred outcome. This peculiar reactivity, explained by a computational study, led to unprecedented bis-azetidinyl-macrocycles acting as potent inhibitors of R39 D,D-carboxypeptidase, a bacterial model enzyme for PBPs." @default.
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• W1974435880 date "2010-12-01" @default.
• W1974435880 modified "2023-09-23" @default.
• W1974435880 title "Cyclodimerization by ring-closing metathesis: synthesis, computational, and biological evaluation of novel bis-azetidinyl-macrocycles" @default.
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• W1974435880 doi "https://doi.org/10.1016/j.tet.2010.10.015" @default.
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