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- W1974443275 abstract "We have investigated the effects of several snake venoms on the Ca2+-dependent K+ channels of human red cells. A heat-resistant component of the venom of the snake Notechis scutatus irreversibly inhibited Ca2+-dependent K+ transport with a Ki value of 0.1-0.2 micrograms/ml. Metabolic changes of the cells modified the maximal effect of the venom. Binding of the venom required extracellular Ca2+ and was quick, but development of full inhibition required additional time. The effects of the venoms from Notechis scutatus and Leiurus quinquestriatus were additive, suggesting that both venoms act through different mechanisms. Venoms of the snakes Vipera russelli russelli and Oxyuranus scutellatus also inhibited Ca2+-dependent K+ transport with the same characteristics as the Notechis scutatus venom." @default.
- W1974443275 created "2016-06-24" @default.
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- W1974443275 date "1989-04-01" @default.
- W1974443275 modified "2023-10-18" @default.
- W1974443275 title "Inhibition of red cell Ca2+-dependent K+ channels by snake venoms" @default.
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- W1974443275 doi "https://doi.org/10.1016/0005-2736(89)90391-x" @default.
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