Matches in SemOpenAlex for { <https://semopenalex.org/work/W1974443507> ?p ?o ?g. }
- W1974443507 endingPage "3697" @default.
- W1974443507 startingPage "3687" @default.
- W1974443507 abstract "The cytotoxic action of some ribonucleases homologous to bovine pancreatic RNase A, the superfamily prototype, has interested and intrigued investigators. Their ribonucleolytic activity is essential for their cytotoxic action, and their target RNA is in the cytosol. It has been proposed that the cytosolic RNase inhibitor (cRI) plays a major role in determining the ability of an RNase to be cytotoxic. However, to interact with cRI RNases must reach the cytosol, and cross intracellular membranes. To investigate the interactions of cytotoxic RNases with membranes, cytotoxic dimeric RNases resistant, or considered to be resistant to cRI, were assayed for their effects on negatively charged membranes. Furthermore, we analyzed the electrostatic interaction energy of the RNases complexed in silico with a model membrane. The results of this study suggest that close correlations can be recognized between the cytotoxic action of a dimeric RNase and its ability to complex and destabilize negatively charged membranes." @default.
- W1974443507 created "2016-06-24" @default.
- W1974443507 creator A5008206928 @default.
- W1974443507 creator A5014568707 @default.
- W1974443507 creator A5025375215 @default.
- W1974443507 creator A5034673695 @default.
- W1974443507 creator A5070660123 @default.
- W1974443507 creator A5073268079 @default.
- W1974443507 date "2006-07-24" @default.
- W1974443507 modified "2023-09-30" @default.
- W1974443507 title "The role of electrostatic interactions in the antitumor activity of dimeric RNases" @default.
- W1974443507 cites W1437642699 @default.
- W1974443507 cites W1484821298 @default.
- W1974443507 cites W14871158 @default.
- W1974443507 cites W150281572 @default.
- W1974443507 cites W1552732056 @default.
- W1974443507 cites W1586992809 @default.
- W1974443507 cites W16268699 @default.
- W1974443507 cites W1635116362 @default.
- W1974443507 cites W167632067 @default.
- W1974443507 cites W1869944834 @default.
- W1974443507 cites W1965434479 @default.
- W1974443507 cites W1970089681 @default.
- W1974443507 cites W1970490331 @default.
- W1974443507 cites W1978421603 @default.
- W1974443507 cites W198030899 @default.
- W1974443507 cites W1991146845 @default.
- W1974443507 cites W1994417790 @default.
- W1974443507 cites W2012074506 @default.
- W1974443507 cites W2015642465 @default.
- W1974443507 cites W2021420392 @default.
- W1974443507 cites W2021717885 @default.
- W1974443507 cites W2024042048 @default.
- W1974443507 cites W2024156929 @default.
- W1974443507 cites W2027305112 @default.
- W1974443507 cites W2036911034 @default.
- W1974443507 cites W2043199702 @default.
- W1974443507 cites W2047134870 @default.
- W1974443507 cites W2048623694 @default.
- W1974443507 cites W2052818438 @default.
- W1974443507 cites W2053643552 @default.
- W1974443507 cites W2055993623 @default.
- W1974443507 cites W2057664120 @default.
- W1974443507 cites W2057970064 @default.
- W1974443507 cites W2060809301 @default.
- W1974443507 cites W2071242462 @default.
- W1974443507 cites W2078504167 @default.
- W1974443507 cites W2088776290 @default.
- W1974443507 cites W2089717292 @default.
- W1974443507 cites W2097919743 @default.
- W1974443507 cites W2103598875 @default.
- W1974443507 cites W2110562802 @default.
- W1974443507 cites W2139875556 @default.
- W1974443507 cites W2144892927 @default.
- W1974443507 cites W2161353052 @default.
- W1974443507 cites W2491796894 @default.
- W1974443507 cites W3022560476 @default.
- W1974443507 doi "https://doi.org/10.1111/j.1742-4658.2006.05373.x" @default.
- W1974443507 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16911519" @default.
- W1974443507 hasPublicationYear "2006" @default.
- W1974443507 type Work @default.
- W1974443507 sameAs 1974443507 @default.
- W1974443507 citedByCount "34" @default.
- W1974443507 countsByYear W19744435072013 @default.
- W1974443507 countsByYear W19744435072014 @default.
- W1974443507 countsByYear W19744435072015 @default.
- W1974443507 countsByYear W19744435072016 @default.
- W1974443507 countsByYear W19744435072017 @default.
- W1974443507 countsByYear W19744435072019 @default.
- W1974443507 countsByYear W19744435072020 @default.
- W1974443507 countsByYear W19744435072021 @default.
- W1974443507 countsByYear W19744435072022 @default.
- W1974443507 crossrefType "journal-article" @default.
- W1974443507 hasAuthorship W1974443507A5008206928 @default.
- W1974443507 hasAuthorship W1974443507A5014568707 @default.
- W1974443507 hasAuthorship W1974443507A5025375215 @default.
- W1974443507 hasAuthorship W1974443507A5034673695 @default.
- W1974443507 hasAuthorship W1974443507A5070660123 @default.
- W1974443507 hasAuthorship W1974443507A5073268079 @default.
- W1974443507 hasBestOaLocation W19744435071 @default.
- W1974443507 hasConcept C104317684 @default.
- W1974443507 hasConcept C10879258 @default.
- W1974443507 hasConcept C12554922 @default.
- W1974443507 hasConcept C154317977 @default.
- W1974443507 hasConcept C181199279 @default.
- W1974443507 hasConcept C185592680 @default.
- W1974443507 hasConcept C202751555 @default.
- W1974443507 hasConcept C2775905019 @default.
- W1974443507 hasConcept C2778976237 @default.
- W1974443507 hasConcept C41625074 @default.
- W1974443507 hasConcept C55493867 @default.
- W1974443507 hasConcept C67705224 @default.
- W1974443507 hasConcept C79879829 @default.
- W1974443507 hasConcept C86803240 @default.
- W1974443507 hasConcept C95444343 @default.
- W1974443507 hasConcept C98539663 @default.
- W1974443507 hasConceptScore W1974443507C104317684 @default.
- W1974443507 hasConceptScore W1974443507C10879258 @default.