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- W1974445768 abstract "Streptochlorin, first isolated as a new antibiotic in 1988 from the lipophilic extracts of the mycelium of a Streptomyces sp, is an indole natural products with a variety of biological activities. Based on the methods developed for the synthesis of pimprinine in our laboratory, we have synthesized a series of indole-modified streptochlorin analogues and measured their activities against seven phytopathogenic fungi. Some of the analogues displayed good activity in the primary assays, and the seven compounds 10b, 10c, 11e, 13e, 21, 22c and 22e (shown in Figure 1) were identified as the most promising candidates for further study. Structural optimization is still ongoing with the aim of discovering synthetic analogues with improved antifungal activity." @default.
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- W1974445768 date "2015-03-01" @default.
- W1974445768 modified "2023-10-09" @default.
- W1974445768 title "Synthesis and antifungal activity of novel streptochlorin analogues" @default.
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- W1974445768 doi "https://doi.org/10.1016/j.ejmech.2015.01.043" @default.
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