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- W1974448220 abstract "Ribavirin and 2′-O-methylcytidine 5′-phosphoramidates derived from L-alanine methyl ester bearing either an O-phenyl or a biodegradable O-[3-(acetyloxy)-2,2-bis(ethoxycarbonyl)propyl] or O-[3-(acetyloxymethoxy)-2,2-bis(ethoxycarbonyl)propyl] protecting group were prepared. The kinetics of the deprotection of these pro-drugs by porcine liver esterase and by a whole cell extract of human prostate carcinoma was studied by HPLC-ESI-MS/MS. The 3-(acetyloxymethoxy)-2,2-bis(ethoxycarbonyl)propyl and 3-(acetyloxy)-2,2-bis(ethoxycarbonyl)propyl groups were readily removed releasing the L-alanine methyl ester phosphoramidate nucleotide, the deprotection of the 3-(acetyloxymethoxy) derivative being approximately 20 times faster. The chemical stability of the 2′-O-methylcytidine pro-drugs was additionally determined over a pH range from 7.5 to 10." @default.
- W1974448220 created "2016-06-24" @default.
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- W1974448220 date "2010-01-01" @default.
- W1974448220 modified "2023-10-16" @default.
- W1974448220 title "Chemical and enzymatic stability of amino acid derived phosphoramidates of antiviral nucleoside 5′-monophosphates bearing a biodegradable protecting group" @default.
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- W1974448220 doi "https://doi.org/10.1039/b924321f" @default.
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