FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1974458512> ?p ?o ?g. }

• W1974458512 endingPage "1745" @default.
• W1974458512 startingPage "1740" @default.
• W1974458512 abstract "Alcohol's suppressive effects on polymorphonuclear leukocyte (PMN) production and function increases host susceptibility to a wide variety of infections and impairs the ability of these effector cells to seek and destroy invading pathogens. Granulocyte colony-stimulating factor (G-CSF), an important regulator of PMN production and function, is known to be increased in the plasma during infectious episodes. In previous studies we found acute alcohol intoxication to suppress the tumor necrosis factor-alpha (TNF alpha) response to in vivo challenges with bacteria or lipopolysaccharide. The present study was initiated to determine the impact of alcohol intoxication on the plasma G-CSF response to gram-negative infection. For this purpose, rats received an intravenous challenge of Escherichia coli (10(6) CFU) 30 min after an intraperitoneal injection of ethanol (5.5 g/kg) or an equivalent volume of saline (control). Ethanol-intoxicated rats had a greater 48 hr mortality to live E. coli injection than did unintoxicated animals (45% vs. 8%). Despite an increased bacterial burden in both the lung and liver at 24 hr after initiating E. coli infection in alcohol-intoxicated animals, PMN tissue recruitment, indexed as myeloperoxidase activity, did not differ between control and alcohol-treated rats. Moreover, alcohol suppressed blood PMN phagocytic capacity to a greater extent in animals given alcohol than controls at 5 and 24 hr after initiating infection. In control animals after intravenous E. coli injection, bioactive G-CSF increased in plasma and peaked near 300 ng/ml at 8 hr. In rats pretreated with alcohol, the plasma G-CSF response was markedly suppressed in response to intravenous E. coli (p < 0.05). In a second experiment, neutralization of the E. coli-induced plasma TNF alpha response by pretreatment with anti-TNF alpha antibody similarly inhibited the plasma G-CSF response. These results support the postulate that alcohol-induced inhibition of TNF alpha directly contributes to the adverse effects of alcohol on PMN function by suppressing the normal autocrine amplification pathway responsible for G-CSF production." @default.
• W1974458512 created "2016-06-24" @default.
• W1974458512 creator A5022422924 @default.
• W1974458512 creator A5029247654 @default.
• W1974458512 creator A5055151897 @default.
• W1974458512 creator A5086871896 @default.
• W1974458512 date "1998-11-01" @default.
• W1974458512 modified "2023-09-28" @default.
• W1974458512 title "Suppression of the Granulocyte Colony-Stimulating Factor Response to Escherichia coli Challenge by Alcohol Intoxication" @default.
• W1974458512 cites W12954242 @default.
• W1974458512 cites W1969411212 @default.
• W1974458512 cites W198853106 @default.
• W1974458512 cites W1991336686 @default.
• W1974458512 cites W1999298222 @default.
• W1974458512 cites W2010444443 @default.
• W1974458512 cites W2019404429 @default.
• W1974458512 cites W2023758601 @default.
• W1974458512 cites W2029200627 @default.
• W1974458512 cites W2030235062 @default.
• W1974458512 cites W2031873118 @default.
• W1974458512 cites W2040929955 @default.
• W1974458512 cites W2046433797 @default.
• W1974458512 cites W2051651163 @default.
• W1974458512 cites W2054526986 @default.
• W1974458512 cites W2054564332 @default.
• W1974458512 cites W2076777813 @default.
• W1974458512 cites W2077086034 @default.
• W1974458512 cites W2086719170 @default.
• W1974458512 cites W2090954918 @default.
• W1974458512 cites W2092897179 @default.
• W1974458512 cites W2094033013 @default.
• W1974458512 cites W2101366590 @default.
• W1974458512 cites W2109754197 @default.
• W1974458512 cites W2133983830 @default.
• W1974458512 cites W2149181464 @default.
• W1974458512 cites W2152434300 @default.
• W1974458512 cites W2239119657 @default.
• W1974458512 cites W2270245312 @default.
• W1974458512 cites W2314427160 @default.
• W1974458512 cites W2321969314 @default.
• W1974458512 cites W2326243556 @default.
• W1974458512 cites W2332083038 @default.
• W1974458512 cites W2332955492 @default.
• W1974458512 cites W2335003614 @default.
• W1974458512 cites W248318794 @default.
• W1974458512 cites W51804427 @default.
• W1974458512 doi "https://doi.org/10.1111/j.1530-0277.1998.tb03974.x" @default.
• W1974458512 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9835289" @default.
• W1974458512 hasPublicationYear "1998" @default.
• W1974458512 type Work @default.
• W1974458512 sameAs 1974458512 @default.
• W1974458512 citedByCount "59" @default.
• W1974458512 countsByYear W19744585122012 @default.
• W1974458512 countsByYear W19744585122013 @default.
• W1974458512 countsByYear W19744585122014 @default.
• W1974458512 countsByYear W19744585122015 @default.
• W1974458512 countsByYear W19744585122017 @default.
• W1974458512 countsByYear W19744585122019 @default.
• W1974458512 countsByYear W19744585122020 @default.
• W1974458512 countsByYear W19744585122022 @default.
• W1974458512 crossrefType "journal-article" @default.
• W1974458512 hasAuthorship W1974458512A5022422924 @default.
• W1974458512 hasAuthorship W1974458512A5029247654 @default.
• W1974458512 hasAuthorship W1974458512A5055151897 @default.
• W1974458512 hasAuthorship W1974458512A5086871896 @default.
• W1974458512 hasConcept C104317684 @default.
• W1974458512 hasConcept C126322002 @default.
• W1974458512 hasConcept C134018914 @default.
• W1974458512 hasConcept C150903083 @default.
• W1974458512 hasConcept C17991360 @default.
• W1974458512 hasConcept C203014093 @default.
• W1974458512 hasConcept C203565725 @default.
• W1974458512 hasConcept C207001950 @default.
• W1974458512 hasConcept C2776914184 @default.
• W1974458512 hasConcept C2777397205 @default.
• W1974458512 hasConcept C2777983669 @default.
• W1974458512 hasConcept C2778754761 @default.
• W1974458512 hasConcept C2780159080 @default.
• W1974458512 hasConcept C2780161600 @default.
• W1974458512 hasConcept C2781066024 @default.
• W1974458512 hasConcept C547475151 @default.
• W1974458512 hasConcept C55493867 @default.
• W1974458512 hasConcept C71924100 @default.
• W1974458512 hasConcept C86803240 @default.
• W1974458512 hasConcept C89423630 @default.
• W1974458512 hasConcept C98274493 @default.
• W1974458512 hasConceptScore W1974458512C104317684 @default.
• W1974458512 hasConceptScore W1974458512C126322002 @default.
• W1974458512 hasConceptScore W1974458512C134018914 @default.
• W1974458512 hasConceptScore W1974458512C150903083 @default.
• W1974458512 hasConceptScore W1974458512C17991360 @default.
• W1974458512 hasConceptScore W1974458512C203014093 @default.
• W1974458512 hasConceptScore W1974458512C203565725 @default.
• W1974458512 hasConceptScore W1974458512C207001950 @default.
• W1974458512 hasConceptScore W1974458512C2776914184 @default.
• W1974458512 hasConceptScore W1974458512C2777397205 @default.
• W1974458512 hasConceptScore W1974458512C2777983669 @default.
• W1974458512 hasConceptScore W1974458512C2778754761 @default.

• next