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- W1974460537 abstract "Editorial Notes1 April 1971Analgesics, Hemolysis, and SplenomegalyANTHONY V. PISCIOTTA, M.D., F.A.C.P.ANTHONY V. PISCIOTTA, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-74-4-634 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptModern chemistry has not been entirely kind to man. With accumulating experience, it becomes more and more evident that some of our most widely used and apparently innocuous drugs have toxic properties. Even the analgesics aspirin and phenacetin, found in everyone's medicine cabinet, have been implicated in producing serious disease states.The most frequently implicated component of analgesic mixtures has been phenacetin. Its most obvious toxic effect, and therefore the first to be discovered, is cyanosis, which may follow ingestion of over 1 g of phenacetin daily for months. The cyanosis is a consequence of the accumulation of nonfunctioning sulf-hemoglobin...References1. GAULTRUDWALENGLES MTW: Syndrome associated with the abuse of analgesics. Ann Intern Med 68:906-925, 1968 LinkGoogle Scholar2. MACGIBBONLOUGHRIDGEHOURIHANE BLD: Autoimmune haemolytic anaemia with acute renal failure due to phenacetin and p-aminosalicylic acid. Lancet 2:7-10, 1960 CrossrefGoogle Scholar3. LORENZEDSCHWARTZ IM: Phenacetin-induced haemolysis in patients with chronic nephritis and phenacetin abuse. Acta Med Scand 168:461-466, 1970 CrossrefGoogle Scholar4. FORDHAMHUFFINES CW: Splenomegaly, analgesic ingestion and renal disease. New Eng J Med 14:749-751, 1967 CrossrefGoogle Scholar5. SCHNITZERSMITH BE: Observations of phagocytized red cells containing Heinz bodies. A light and electron microscopic study. Amer J Clin Path 46:538-545, 1966 CrossrefMedlineGoogle Scholar6. DUGGAN J: Splenomegaly in analgesic takers. Med J Aust Sept. 26, 580-583, 1970 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Milwaukee County General Hospital Milwaukee, Wis. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1971Volume 74, Issue 4Page: 634-635KeywordsAnalgesicsAspirinDrugsIngestionSplenomegaly Issue Published: 1 April 1971 PDF downloadLoading ..." @default.
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- W1974460537 title "Analgesics, Hemolysis, and Splenomegaly" @default.
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