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- W1974468564 abstract "A novel HeartPatch® DCC device has been shown to effectively restore cardiac output (CO) and blood pressure (BP) in moderate acute HF sheep. Preliminary data also suggests the device is able to restore these parameters in awake sheep with asystolic hearts. This study examined the efficacy of the device and the response of left ventricular pressure (LVP) in anesthetized sheep with KCI-induced asystole. Five sheep (55 ± 5 kg) were implanted with left and right ventricular DCC patches two weeks prior to study. A flow probe on the ascending aorta measured CO and a Millar pressure catheter measured LVP. Asystole was induced with i.v. KCl (2g). The device, driven by an extracorporeal pneumatic driver at 108 5 8 beats.min−1and 207 ± 19 mmHg, was able to restore hemodynamic parameters (Table).TableAfter 30 min DCC assist, normal sinus rhythm was restored in four of the five sheep, followed by complete recovery. We conclude that a simple to implant, nun-blood contacting DCC device reverses hemodynamic abnormalities in anesthetized asystolic sheep. The device increases LV systolic pressure beyond baseline and simultaneously restores LV diastolic pressure." @default.
- W1974468564 created "2016-06-24" @default.
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- W1974468564 date "2002-03-01" @default.
- W1974468564 modified "2023-09-27" @default.
- W1974468564 title "ASYSTOLIC HEART EFFECTIVELY SUPPORTED BY HEARTPATCH® DIRECT CARDIAC COMPRESSION (DCC) IN ANESTHETIZED SHEEP ROLE OF LV PRESSURE" @default.
- W1974468564 doi "https://doi.org/10.1097/00002480-200203000-00036" @default.
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