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- W1974475852 abstract "Fe2+/ascorbate-induced peroxidation of isolated rat liver mitochondria leads to initial volume changes and, ultimately, to severe damage characterized by gross swelling and loss of cristae and matrix material. Only the last phase is associated with significant production of malondialdehyde. The shrinkage of mitochondria during the onset of peroxidation matches changes observed in mitochondria of aging animals. Thioctacid (alpha-lipoic acid) prevents this initial shrinkage. However, its main effect in the system studied here is inhibition of active respiration." @default.
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- W1974475852 date "1991-03-01" @default.
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- W1974475852 title "Morphological changes of isolated rat liver mitochondria during Fe2+/ascorbate-induced peroxidation and the effect of thioctacid" @default.
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- W1974475852 doi "https://doi.org/10.1016/0047-6374(91)90049-6" @default.
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