Matches in SemOpenAlex for { <https://semopenalex.org/work/W1974485986> ?p ?o ?g. }
- W1974485986 endingPage "105" @default.
- W1974485986 startingPage "105" @default.
- W1974485986 abstract "The serine-threonine kinase receptor-associated protein (STRAP) was initially identified as a putative inhibitor of the canonical TGF-beta signaling pathway. Because the Smad-dependent TGF-beta pathway negatively regulates cellular growth, early functional studies suggested that STRAP behaves as an oncogene. Indeed, a correlation between STRAP overexpression and various cancers has been identified. With the emergence of new studies on the biological function of STRAP, it is becoming clear that STRAP regulates several distinct cellular processes and modulates multiple signaling pathways. While STRAP itself does not possess enzymatic activity, it appears that STRAP influences biological processes through associations with cellular proteins. In this review, we will describe the TGF-beta-dependent and -independent functions of STRAP and provide a context for the significance of STRAP activity in the development of cancer." @default.
- W1974485986 created "2016-06-24" @default.
- W1974485986 creator A5013835810 @default.
- W1974485986 creator A5071320688 @default.
- W1974485986 date "2011-01-01" @default.
- W1974485986 modified "2023-09-25" @default.
- W1974485986 title "TGF-beta-dependent and -independent roles of STRAP in cancer" @default.
- W1974485986 cites W108593966 @default.
- W1974485986 cites W1486583495 @default.
- W1974485986 cites W1520109974 @default.
- W1974485986 cites W1533548496 @default.
- W1974485986 cites W1553444759 @default.
- W1974485986 cites W1589859980 @default.
- W1974485986 cites W1789215739 @default.
- W1974485986 cites W1858634947 @default.
- W1974485986 cites W1955222620 @default.
- W1974485986 cites W1967603130 @default.
- W1974485986 cites W1970136142 @default.
- W1974485986 cites W1974939794 @default.
- W1974485986 cites W1978785485 @default.
- W1974485986 cites W1980849677 @default.
- W1974485986 cites W1986407289 @default.
- W1974485986 cites W1988942273 @default.
- W1974485986 cites W1989132136 @default.
- W1974485986 cites W1992468405 @default.
- W1974485986 cites W1997135088 @default.
- W1974485986 cites W1999936156 @default.
- W1974485986 cites W2001265928 @default.
- W1974485986 cites W2001778920 @default.
- W1974485986 cites W2006393800 @default.
- W1974485986 cites W2014091091 @default.
- W1974485986 cites W2016541955 @default.
- W1974485986 cites W2018875909 @default.
- W1974485986 cites W2019453558 @default.
- W1974485986 cites W2020989705 @default.
- W1974485986 cites W2023734637 @default.
- W1974485986 cites W2023928593 @default.
- W1974485986 cites W2025989401 @default.
- W1974485986 cites W2035653659 @default.
- W1974485986 cites W2039907359 @default.
- W1974485986 cites W2040767945 @default.
- W1974485986 cites W2041757531 @default.
- W1974485986 cites W2042999583 @default.
- W1974485986 cites W2046045619 @default.
- W1974485986 cites W2054446479 @default.
- W1974485986 cites W2056852515 @default.
- W1974485986 cites W2060717870 @default.
- W1974485986 cites W2060818930 @default.
- W1974485986 cites W2069232844 @default.
- W1974485986 cites W2069924164 @default.
- W1974485986 cites W2075897532 @default.
- W1974485986 cites W2084296291 @default.
- W1974485986 cites W2084702659 @default.
- W1974485986 cites W2087215271 @default.
- W1974485986 cites W2088358109 @default.
- W1974485986 cites W2090644462 @default.
- W1974485986 cites W2090915824 @default.
- W1974485986 cites W2093833484 @default.
- W1974485986 cites W2094670061 @default.
- W1974485986 cites W2094709780 @default.
- W1974485986 cites W2099571103 @default.
- W1974485986 cites W2099632290 @default.
- W1974485986 cites W2105542427 @default.
- W1974485986 cites W2105824620 @default.
- W1974485986 cites W2107999044 @default.
- W1974485986 cites W2112655704 @default.
- W1974485986 cites W2114191414 @default.
- W1974485986 cites W2114591766 @default.
- W1974485986 cites W2120752885 @default.
- W1974485986 cites W2121882364 @default.
- W1974485986 cites W2125858522 @default.
- W1974485986 cites W2129003871 @default.
- W1974485986 cites W2129295778 @default.
- W1974485986 cites W2129315871 @default.
- W1974485986 cites W2129372622 @default.
- W1974485986 cites W2131606477 @default.
- W1974485986 cites W2132997519 @default.
- W1974485986 cites W2138472451 @default.
- W1974485986 cites W2141163387 @default.
- W1974485986 cites W2142250806 @default.
- W1974485986 cites W2149715294 @default.
- W1974485986 cites W2151788284 @default.
- W1974485986 cites W2158677462 @default.
- W1974485986 cites W2163184605 @default.
- W1974485986 cites W2164552220 @default.
- W1974485986 cites W2168189152 @default.
- W1974485986 cites W2169062791 @default.
- W1974485986 cites W2316475751 @default.
- W1974485986 cites W2326007095 @default.
- W1974485986 doi "https://doi.org/10.2741/3678" @default.
- W1974485986 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4281466" @default.
- W1974485986 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21196161" @default.
- W1974485986 hasPublicationYear "2011" @default.
- W1974485986 type Work @default.
- W1974485986 sameAs 1974485986 @default.
- W1974485986 citedByCount "24" @default.
- W1974485986 countsByYear W19744859862012 @default.
- W1974485986 countsByYear W19744859862013 @default.