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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1974489757> ?p ?o ?g. }

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• W1974489757 abstract "Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces apoptosis in a variety of transformed cell lines, but generally spares most normal cells. Transduction by an adenoviral vector expressing human TRAIL cDNA (Ad.TRAIL-GFP) resulted in both direct tumor cell killing as well as a potent bystander effect through presentation of TRAIL by transduced normal cells. Administration of Ad.TRAIL-GFP significantly prolonged survival of mice harboring either intracerebral glioblastomas or breast carcinoma-induced peritoneal carcinomatosis. Additionally, TRAIL induced prolonged transgene expression in normal tissue, presumably as a result of diminished immune-mediated destruction of vector-transduced cells. Taken together, these data suggest that vector-mediated transduction of TRAIL may represent an effective strategy for cancer gene therapy." @default.
• W1974489757 created "2016-06-24" @default.
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• W1974489757 date "2002-01-01" @default.
• W1974489757 modified "2023-09-23" @default.
• W1974489757 title "Antitumor Activity and Prolonged Expression from a TRAIL-Expressing Adenoviral Vector" @default.
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• W1974489757 doi "https://doi.org/10.1038/sj.neo.7900245" @default.
• W1974489757 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1531709" @default.
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