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- W1974490103 abstract "Twenty-one patients with advanced malignancies who had exhausted or refused conventional modalities of treatment were entered in a Phase I toxicology trial of active specific intralymphatic immunotherapy (ASILI). The patients were immunized with 1 × 107 to 1.2 × 108 viable autochthonous or allogeneic irradiated tumor cells intralymphatically each month and received no other antineoplastic treatment. To date, 274 intralymphatic injections have been performed and except for one case of bacterial lymphangitis, no adverse side effects have been observed. ASILI did not significantly alter peripheral blood lymphocyte counts, absolute E-rosette forming cell levels, or EA-rosette forming cell levels. PHA reactivity of peripheral blood lymphocytes increased slightly in all but one patient tested. Seven out of nine patients who had not had delayed hypersensitivity to recall antigens developed positive reactions following ASILI. Sixteen out of twenty patients tested also developed reactivity to their immunizing cells after treatment. Objective regression (greater than 50% reduction of tumor mass) was observed in five out of nineteen evaluable patients. Six patients showed stabilization of tumor growth and eight patients continued to progress under treatment." @default.
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- W1974490103 date "1978-06-01" @default.
- W1974490103 modified "2023-10-15" @default.
- W1974490103 title "A phase I study of active specific intralymphatic immunotherapy (ASILI)" @default.
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- W1974490103 doi "https://doi.org/10.1002/1097-0142(197806)41:6<2215::aid-cncr2820410622>3.0.co;2-x" @default.
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