Matches in SemOpenAlex for { <https://semopenalex.org/work/W1974495178> ?p ?o ?g. }
- W1974495178 endingPage "114" @default.
- W1974495178 startingPage "107" @default.
- W1974495178 abstract "Summary Background Steatosis in chronic hepatitis C is associated with inflammation and accelerated fibrogenesis. Aim To assess the contribution of peroxisome proliferator‐activated receptor‐ α and ‐ γ to the pathogenesis of hepatitis C virus associated steatosis is unknown. Methods We measured peroxisome proliferator‐activated receptor (PPAR)‐ α and ‐ γ mRNA by quantitative polymerase chain reaction in liver biopsies of 35 genotype 1 and 22 genotype 3 infected patients and in Huh7 cells expressing hepatitis C virus 1b or 3a core protein. Results PPAR‐ α mRNA was significantly reduced in livers of patients with genotype 3 compared with genotype 1. Steatosis was associated to a decreased expression of PPAR‐ α in genotype 1, but not in genotype 3. PPAR‐ γ expression was significantly lower in genotype 3 compared with genotype 1 and steatosis was associated to decreased levels of PPAR‐ γ , but only in genotype 1. There was no significant relationship between PPARs mRNA levels and liver activity or fibrosis. Expression of the hepatitis C virus 3a core protein was associated with an increase in triglyceride accumulation and with a significant reduction of PPAR‐ γ mRNA compared with hepatitis C virus 1b. Conclusions The presence of steatosis and hepatitis C virus genotype 3 are both associated with a significant down‐regulation of PPARs. These receptors, and also additional factors, seem to play a role in the pathogenesis of hepatitis C virus‐associated steatosis." @default.
- W1974495178 created "2016-06-24" @default.
- W1974495178 creator A5004008262 @default.
- W1974495178 creator A5004642302 @default.
- W1974495178 creator A5014434525 @default.
- W1974495178 creator A5026722725 @default.
- W1974495178 creator A5028402758 @default.
- W1974495178 creator A5060333134 @default.
- W1974495178 creator A5064451267 @default.
- W1974495178 creator A5073307450 @default.
- W1974495178 creator A5085445167 @default.
- W1974495178 date "2005-12-13" @default.
- W1974495178 modified "2023-10-18" @default.
- W1974495178 title "Peroxisome proliferator-activated receptor-alpha and -gamma mRNA levels are reduced in chronic hepatitis C with steatosis and genotype 3 infection" @default.
- W1974495178 cites W1485363385 @default.
- W1974495178 cites W1963533730 @default.
- W1974495178 cites W1968375269 @default.
- W1974495178 cites W1972559150 @default.
- W1974495178 cites W1975004114 @default.
- W1974495178 cites W1976648979 @default.
- W1974495178 cites W1986838881 @default.
- W1974495178 cites W2009575651 @default.
- W1974495178 cites W2025657436 @default.
- W1974495178 cites W2027545702 @default.
- W1974495178 cites W2036550935 @default.
- W1974495178 cites W2039857559 @default.
- W1974495178 cites W2054144404 @default.
- W1974495178 cites W2055628636 @default.
- W1974495178 cites W2061361002 @default.
- W1974495178 cites W2062225736 @default.
- W1974495178 cites W2064590565 @default.
- W1974495178 cites W2075293916 @default.
- W1974495178 cites W2078176020 @default.
- W1974495178 cites W2085070297 @default.
- W1974495178 cites W2092621119 @default.
- W1974495178 cites W2107752044 @default.
- W1974495178 cites W2109457390 @default.
- W1974495178 cites W2120432009 @default.
- W1974495178 cites W2125946144 @default.
- W1974495178 cites W2127685726 @default.
- W1974495178 cites W2130618859 @default.
- W1974495178 cites W2145174917 @default.
- W1974495178 cites W2157433311 @default.
- W1974495178 cites W2163207725 @default.
- W1974495178 cites W2163991469 @default.
- W1974495178 cites W2166045485 @default.
- W1974495178 cites W2169151999 @default.
- W1974495178 cites W2224030459 @default.
- W1974495178 cites W4245059944 @default.
- W1974495178 cites W4251925572 @default.
- W1974495178 doi "https://doi.org/10.1111/j.1365-2036.2006.02729.x" @default.
- W1974495178 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16393287" @default.
- W1974495178 hasPublicationYear "2005" @default.
- W1974495178 type Work @default.
- W1974495178 sameAs 1974495178 @default.
- W1974495178 citedByCount "112" @default.
- W1974495178 countsByYear W19744951782012 @default.
- W1974495178 countsByYear W19744951782013 @default.
- W1974495178 countsByYear W19744951782014 @default.
- W1974495178 countsByYear W19744951782015 @default.
- W1974495178 countsByYear W19744951782016 @default.
- W1974495178 countsByYear W19744951782017 @default.
- W1974495178 countsByYear W19744951782018 @default.
- W1974495178 countsByYear W19744951782019 @default.
- W1974495178 countsByYear W19744951782021 @default.
- W1974495178 countsByYear W19744951782022 @default.
- W1974495178 crossrefType "journal-article" @default.
- W1974495178 hasAuthorship W1974495178A5004008262 @default.
- W1974495178 hasAuthorship W1974495178A5004642302 @default.
- W1974495178 hasAuthorship W1974495178A5014434525 @default.
- W1974495178 hasAuthorship W1974495178A5026722725 @default.
- W1974495178 hasAuthorship W1974495178A5028402758 @default.
- W1974495178 hasAuthorship W1974495178A5060333134 @default.
- W1974495178 hasAuthorship W1974495178A5064451267 @default.
- W1974495178 hasAuthorship W1974495178A5073307450 @default.
- W1974495178 hasAuthorship W1974495178A5085445167 @default.
- W1974495178 hasBestOaLocation W19744951781 @default.
- W1974495178 hasConcept C104317684 @default.
- W1974495178 hasConcept C126322002 @default.
- W1974495178 hasConcept C134018914 @default.
- W1974495178 hasConcept C135763542 @default.
- W1974495178 hasConcept C159047783 @default.
- W1974495178 hasConcept C170493617 @default.
- W1974495178 hasConcept C187345961 @default.
- W1974495178 hasConcept C2522874641 @default.
- W1974495178 hasConcept C2776175330 @default.
- W1974495178 hasConcept C2776408679 @default.
- W1974495178 hasConcept C2780942790 @default.
- W1974495178 hasConcept C55493867 @default.
- W1974495178 hasConcept C71924100 @default.
- W1974495178 hasConcept C86803240 @default.
- W1974495178 hasConceptScore W1974495178C104317684 @default.
- W1974495178 hasConceptScore W1974495178C126322002 @default.
- W1974495178 hasConceptScore W1974495178C134018914 @default.
- W1974495178 hasConceptScore W1974495178C135763542 @default.
- W1974495178 hasConceptScore W1974495178C159047783 @default.
- W1974495178 hasConceptScore W1974495178C170493617 @default.
- W1974495178 hasConceptScore W1974495178C187345961 @default.