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• W1974496938 abstract "Wyman JB, Dent J, Holloway RH. Changes in oesophageal pH associated with gastro-oesophageal reflux. Are traditional criteria sensitive for detection of reflux? Scand J Gastroenterol 1993;28:827-832.Traditionally, gastro-oesophageal reflux is deemed to have occurred when oesophageal pH falls below 4. Other ‘non-traditional’ pH changes that do not fall below pH4, that fall below 4 for only brief intervals, or that occur when basal pH is less than 4 are usually disregarded. The aim of this study was to determine whether these non-traditional pH changes represent gastro-oesophageal reflux or are artefactual. The 3-h postprandial combined oesophageal pH and manometric records of 22 patients referred for investigation of suspected gastro-oesophageal reflux were reviewed. All pH falls of ≥0.5 pH units were analysed for manometric evidence of reflux that was classified as definite, probable, or possible. In total, 196 traditional and 223 non-traditional pH events were scored and analysed. The majority of traditional (80%) and non-traditional (60%) events were associated with definite manometric evidence of reflux, although a greater proportion of non-traditional events were associated with only probable evidence of reflux (33%) compared with traditional events (18%). The proportions of possible reflux were similar in the two groups. Limiting pH events to only those satisfying traditional criteria excluded an additional 32% with definite manometric evidence of reflux and 49% with definite or probable evidence of reflux. Most pH falls that remained above 4 or fell across 4 for <15 sec occurred in the 1st h postprandially, compared with traditional pH events, which occurred equally throughout the 3-h period. We conclude that traditional criteria for scoring pH episodes substantially underestimate the number of reflux episodes." @default.
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• W1974496938 date "1993-01-01" @default.
• W1974496938 modified "2023-09-23" @default.
• W1974496938 title "Changes in Oesophageal pH Associated with Gastro-Oesophageal Reflux: Are Traditional Criteria Sensitive for Detection of Reflux?" @default.
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• W1974496938 doi "https://doi.org/10.3109/00365529309104017" @default.
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