Matches in SemOpenAlex for { <https://semopenalex.org/work/W1974501985> ?p ?o ?g. }
- W1974501985 endingPage "3203" @default.
- W1974501985 startingPage "3193" @default.
- W1974501985 abstract "During neurogenesis in the medulla of the Drosophila optic lobe, neuroepithelial cells are programmed to differentiate into neuroblasts at the medial edge of the developing optic lobe. The wave of differentiation progresses synchronously in a row of cells from medial to the lateral regions of the optic lobe, sweeping across the entire neuroepithelial sheet; it is preceded by the transient expression of the proneural gene lethal of scute [l(1)sc] and is thus called the proneural wave. We found that the epidermal growth factor receptor (EGFR) signaling pathway promotes proneural wave progression. EGFR signaling is activated in neuroepithelial cells and induces l(1)sc expression. EGFR activation is regulated by transient expression of Rhomboid (Rho), which is required for the maturation of the EGF ligand Spitz. Rho expression is also regulated by the EGFR signal. The transient and spatially restricted expression of Rho generates sequential activation of EGFR signaling and assures the directional progression of the differentiation wave. This study also provides new insights into the role of Notch signaling. Expression of the Notch ligand Delta is induced by EGFR, and Notch signaling prolongs the proneural state. Notch signaling activity is downregulated by its own feedback mechanism that permits cells at proneural states to subsequently develop into neuroblasts. Thus, coordinated sequential action of the EGFR and Notch signaling pathways causes the proneural wave to progress and induce neuroblast formation in a precisely ordered manner." @default.
- W1974501985 created "2016-06-24" @default.
- W1974501985 creator A5045770446 @default.
- W1974501985 creator A5068693891 @default.
- W1974501985 creator A5083500202 @default.
- W1974501985 creator A5086823047 @default.
- W1974501985 date "2010-10-01" @default.
- W1974501985 modified "2023-10-10" @default.
- W1974501985 title "Coordinated sequential action of EGFR and Notch signaling pathways regulates proneural wave progression in the <i>Drosophila</i> optic lobe" @default.
- W1974501985 cites W1245819034 @default.
- W1974501985 cites W1782083210 @default.
- W1974501985 cites W1807161409 @default.
- W1974501985 cites W1848130254 @default.
- W1974501985 cites W1866472634 @default.
- W1974501985 cites W1885602684 @default.
- W1974501985 cites W1970396586 @default.
- W1974501985 cites W1977468876 @default.
- W1974501985 cites W1981360723 @default.
- W1974501985 cites W1985456400 @default.
- W1974501985 cites W1989575185 @default.
- W1974501985 cites W1996605851 @default.
- W1974501985 cites W1997856028 @default.
- W1974501985 cites W1999529317 @default.
- W1974501985 cites W2010278515 @default.
- W1974501985 cites W2011405275 @default.
- W1974501985 cites W2021766626 @default.
- W1974501985 cites W2030867907 @default.
- W1974501985 cites W2033582979 @default.
- W1974501985 cites W2036207377 @default.
- W1974501985 cites W2038560503 @default.
- W1974501985 cites W2039806395 @default.
- W1974501985 cites W2039942560 @default.
- W1974501985 cites W2040107912 @default.
- W1974501985 cites W2043644025 @default.
- W1974501985 cites W2043723316 @default.
- W1974501985 cites W2047578520 @default.
- W1974501985 cites W2052078486 @default.
- W1974501985 cites W2056032485 @default.
- W1974501985 cites W2056069458 @default.
- W1974501985 cites W2063206483 @default.
- W1974501985 cites W2072966096 @default.
- W1974501985 cites W2082275759 @default.
- W1974501985 cites W2086248842 @default.
- W1974501985 cites W2087575288 @default.
- W1974501985 cites W2088709710 @default.
- W1974501985 cites W2090698995 @default.
- W1974501985 cites W2095168793 @default.
- W1974501985 cites W2096658690 @default.
- W1974501985 cites W2099735892 @default.
- W1974501985 cites W2100256750 @default.
- W1974501985 cites W2101328157 @default.
- W1974501985 cites W2104262655 @default.
- W1974501985 cites W2106921662 @default.
- W1974501985 cites W2111976316 @default.
- W1974501985 cites W2113538446 @default.
- W1974501985 cites W2115343151 @default.
- W1974501985 cites W2120525124 @default.
- W1974501985 cites W2122813534 @default.
- W1974501985 cites W2122841055 @default.
- W1974501985 cites W2131597334 @default.
- W1974501985 cites W2131928323 @default.
- W1974501985 cites W2133708115 @default.
- W1974501985 cites W2138122506 @default.
- W1974501985 cites W2138301962 @default.
- W1974501985 cites W2144868620 @default.
- W1974501985 cites W2150972545 @default.
- W1974501985 cites W2167915180 @default.
- W1974501985 cites W2168948134 @default.
- W1974501985 cites W2184390227 @default.
- W1974501985 cites W2185396472 @default.
- W1974501985 cites W2186225761 @default.
- W1974501985 cites W2188357884 @default.
- W1974501985 cites W2403071997 @default.
- W1974501985 cites W2883167945 @default.
- W1974501985 cites W4232042630 @default.
- W1974501985 cites W4361741107 @default.
- W1974501985 cites W4376848581 @default.
- W1974501985 doi "https://doi.org/10.1242/dev.048058" @default.
- W1974501985 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20724446" @default.
- W1974501985 hasPublicationYear "2010" @default.
- W1974501985 type Work @default.
- W1974501985 sameAs 1974501985 @default.
- W1974501985 citedByCount "95" @default.
- W1974501985 countsByYear W19745019852012 @default.
- W1974501985 countsByYear W19745019852013 @default.
- W1974501985 countsByYear W19745019852014 @default.
- W1974501985 countsByYear W19745019852015 @default.
- W1974501985 countsByYear W19745019852016 @default.
- W1974501985 countsByYear W19745019852017 @default.
- W1974501985 countsByYear W19745019852018 @default.
- W1974501985 countsByYear W19745019852019 @default.
- W1974501985 countsByYear W19745019852020 @default.
- W1974501985 countsByYear W19745019852021 @default.
- W1974501985 countsByYear W19745019852022 @default.
- W1974501985 countsByYear W19745019852023 @default.
- W1974501985 crossrefType "journal-article" @default.
- W1974501985 hasAuthorship W1974501985A5045770446 @default.
- W1974501985 hasAuthorship W1974501985A5068693891 @default.