FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1974503381> ?p ?o ?g. }

• W1974503381 endingPage "491" @default.
• W1974503381 startingPage "482" @default.
• W1974503381 abstract "Thyroid-associated ophthalmopathy (TAO) is an autoimmune disorder that can be divided into three clinical subtypes: congestive, myopathic and mixed ophthalmopathy. It is probably caused by immune cross-reactivity between orbital and thyroid antigens. The best candidate antigens are the thyrotropin receptor and the novel protein, G2s, which is now identified as a fragment of the winged helix transcription factor, FOXP1. The relationship between radioiodine therapy and TAO is controversial, with two randomised controlled trials showing a transient worsening of the eye disease after treatment. The diagnosis of TAO is a clinical one, based on the presence of specific symptoms and signs. Orbital imaging, preferably magnetic resonance imaging, is useful when the diagnosis is in doubt and in patients with suspected optic neuropathy who may benefit from early intervention. Despite their lack of specificity, orbital antibodies may add weight to the diagnosis and may potentially be a useful tool in classifying the different subtypes of TAO and in monitoring disease activity. While antibodies against G2s and the thyrotropin receptor are seen in all subtypes, those against Fp and collagen XIII may be associated with the myopathic and congestive subtypes, respectively, where Fp is the flavoprotein subunit of the mitochondrial enzyme, succinate dehydrogenase. In most patients, TAO is self-limiting and no specific treatment is required. When treatment is indicated, glucocorticoids are the mainstay of therapy. Orbital radiotherapy improves the efficacy of glucocorticoids, but is probably less beneficial as monotherapy. Orbital surgery is best reserved for patients with 'burnt out' inactive disease, but urgent orbital decompression may be required for optic neuropathy. The severity and clinical activity of TAO are important in determining the need for specific treatment and the likelihood of success with medical therapy, respectively." @default.
• W1974503381 created "2016-06-24" @default.
• W1974503381 creator A5012702351 @default.
• W1974503381 creator A5061401133 @default.
• W1974503381 creator A5076913430 @default.
• W1974503381 date "2004-08-01" @default.
• W1974503381 modified "2023-10-15" @default.
• W1974503381 title "Thyroid‐associated ophthalmopathy: a practical guide to classification, natural history and management" @default.
• W1974503381 cites W1257935032 @default.
• W1974503381 cites W1856370030 @default.
• W1974503381 cites W1963639559 @default.
• W1974503381 cites W1974372293 @default.
• W1974503381 cites W1982208000 @default.
• W1974503381 cites W1987200661 @default.
• W1974503381 cites W1987963129 @default.
• W1974503381 cites W1991530007 @default.
• W1974503381 cites W2014266401 @default.
• W1974503381 cites W2018091332 @default.
• W1974503381 cites W2019376418 @default.
• W1974503381 cites W2019875299 @default.
• W1974503381 cites W2024010187 @default.
• W1974503381 cites W2028132006 @default.
• W1974503381 cites W2032054048 @default.
• W1974503381 cites W2039880475 @default.
• W1974503381 cites W2041439225 @default.
• W1974503381 cites W2042945613 @default.
• W1974503381 cites W2046383243 @default.
• W1974503381 cites W2047509736 @default.
• W1974503381 cites W2063476700 @default.
• W1974503381 cites W2073024931 @default.
• W1974503381 cites W2077771027 @default.
• W1974503381 cites W2080560431 @default.
• W1974503381 cites W2081641381 @default.
• W1974503381 cites W2082354904 @default.
• W1974503381 cites W2082745336 @default.
• W1974503381 cites W2084872482 @default.
• W1974503381 cites W2089674018 @default.
• W1974503381 cites W2090514963 @default.
• W1974503381 cites W2093870471 @default.
• W1974503381 cites W2099380557 @default.
• W1974503381 cites W2110096739 @default.
• W1974503381 cites W2110301264 @default.
• W1974503381 cites W2119801377 @default.
• W1974503381 cites W2121070956 @default.
• W1974503381 cites W2126444001 @default.
• W1974503381 cites W2130124581 @default.
• W1974503381 cites W2131516732 @default.
• W1974503381 cites W2131969862 @default.
• W1974503381 cites W2134145268 @default.
• W1974503381 cites W2139030289 @default.
• W1974503381 cites W2139606081 @default.
• W1974503381 cites W2144470478 @default.
• W1974503381 cites W2154999896 @default.
• W1974503381 cites W2155544835 @default.
• W1974503381 cites W2161196093 @default.
• W1974503381 cites W2165714679 @default.
• W1974503381 cites W2169316873 @default.
• W1974503381 cites W2169811058 @default.
• W1974503381 cites W2320293007 @default.
• W1974503381 cites W2334870842 @default.
• W1974503381 cites W2401472776 @default.
• W1974503381 cites W4230812996 @default.
• W1974503381 cites W4232525130 @default.
• W1974503381 cites W4235869967 @default.
• W1974503381 cites W4240244675 @default.
• W1974503381 cites W4242132361 @default.
• W1974503381 cites W4248098588 @default.
• W1974503381 cites W4249373072 @default.
• W1974503381 cites W4250658510 @default.
• W1974503381 cites W4252945096 @default.
• W1974503381 cites W4255173064 @default.
• W1974503381 doi "https://doi.org/10.1111/j.1445-5994.2004.00662.x" @default.
• W1974503381 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15317547" @default.
• W1974503381 hasPublicationYear "2004" @default.
• W1974503381 type Work @default.
• W1974503381 sameAs 1974503381 @default.
• W1974503381 citedByCount "67" @default.
• W1974503381 countsByYear W19745033812012 @default.
• W1974503381 countsByYear W19745033812013 @default.
• W1974503381 countsByYear W19745033812014 @default.
• W1974503381 countsByYear W19745033812015 @default.
• W1974503381 countsByYear W19745033812016 @default.
• W1974503381 countsByYear W19745033812017 @default.
• W1974503381 countsByYear W19745033812018 @default.
• W1974503381 countsByYear W19745033812020 @default.
• W1974503381 countsByYear W19745033812021 @default.
• W1974503381 countsByYear W19745033812022 @default.
• W1974503381 countsByYear W19745033812023 @default.
• W1974503381 crossrefType "journal-article" @default.
• W1974503381 hasAuthorship W1974503381A5012702351 @default.
• W1974503381 hasAuthorship W1974503381A5061401133 @default.
• W1974503381 hasAuthorship W1974503381A5076913430 @default.
• W1974503381 hasConcept C118487528 @default.
• W1974503381 hasConcept C126322002 @default.
• W1974503381 hasConcept C126838900 @default.
• W1974503381 hasConcept C143409427 @default.
• W1974503381 hasConcept C163276114 @default.
• W1974503381 hasConcept C2776652619 @default.

• next