Matches in SemOpenAlex for { <https://semopenalex.org/work/W1974507908> ?p ?o ?g. }
- W1974507908 endingPage "1563" @default.
- W1974507908 startingPage "1552" @default.
- W1974507908 abstract "Abnormal accumulation of β-secretase (BACE1) in dystrophic neurites and presynaptic β-amyloid (Aβ) production contribute to Alzheimer's disease pathogenesis. Little, however, is known about BACE1 sorting and dynamic transport in neurons. We investigated BACE1 trafficking in hippocampal neurons using live-cell imaging and selective labeling. We report that transport vesicles containing internalized BACE1 in dendrites undergo exclusive retrograde transport toward the soma, whereas they undergo bidirectional transport in axons. Unidirectional dendritic transport requires Eps15-homology-domain-containing (EHD) 1 and 3 protein function. Furthermore, loss of EHD function compromises dynamic axonal transport and overall BACE1 levels in axons. EHD1/3 colocalize with BACE1 and APP β-C-terminal fragments in hippocampal mossy fiber terminals, and their depletion in neurons significantly attenuates Aβ levels. These results demonstrate unidirectional endocytic transport of a dendritic cargo and reveal a role for EHD proteins in neuronal BACE1 transcytosis and Aβ production, processes that are highly relevant for Alzheimer’s disease." @default.
- W1974507908 created "2016-06-24" @default.
- W1974507908 creator A5001446897 @default.
- W1974507908 creator A5006901857 @default.
- W1974507908 creator A5015618876 @default.
- W1974507908 creator A5017103335 @default.
- W1974507908 creator A5022413187 @default.
- W1974507908 creator A5024446376 @default.
- W1974507908 creator A5025901197 @default.
- W1974507908 creator A5026286078 @default.
- W1974507908 creator A5026921778 @default.
- W1974507908 creator A5028697711 @default.
- W1974507908 creator A5038280856 @default.
- W1974507908 creator A5052458149 @default.
- W1974507908 creator A5052754408 @default.
- W1974507908 creator A5053939318 @default.
- W1974507908 creator A5071126288 @default.
- W1974507908 creator A5074718111 @default.
- W1974507908 creator A5079927777 @default.
- W1974507908 creator A5082344048 @default.
- W1974507908 date "2013-12-01" @default.
- W1974507908 modified "2023-10-16" @default.
- W1974507908 title "A Function for EHD Family Proteins in Unidirectional Retrograde Dendritic Transport of BACE1 and Alzheimer’s Disease Aβ Production" @default.
- W1974507908 cites W1540823632 @default.
- W1974507908 cites W1557545815 @default.
- W1974507908 cites W1808133217 @default.
- W1974507908 cites W1949229324 @default.
- W1974507908 cites W1955491145 @default.
- W1974507908 cites W1966231010 @default.
- W1974507908 cites W1968900405 @default.
- W1974507908 cites W1978427724 @default.
- W1974507908 cites W1980886192 @default.
- W1974507908 cites W1991625887 @default.
- W1974507908 cites W1997122736 @default.
- W1974507908 cites W2009470502 @default.
- W1974507908 cites W2010416572 @default.
- W1974507908 cites W2015582608 @default.
- W1974507908 cites W2016394661 @default.
- W1974507908 cites W2017001659 @default.
- W1974507908 cites W2046952010 @default.
- W1974507908 cites W2057031451 @default.
- W1974507908 cites W2060351135 @default.
- W1974507908 cites W2061463538 @default.
- W1974507908 cites W2068107769 @default.
- W1974507908 cites W2076185491 @default.
- W1974507908 cites W2078201172 @default.
- W1974507908 cites W2080124845 @default.
- W1974507908 cites W2094625991 @default.
- W1974507908 cites W2095303207 @default.
- W1974507908 cites W2096501276 @default.
- W1974507908 cites W2099634214 @default.
- W1974507908 cites W2100972467 @default.
- W1974507908 cites W2105631420 @default.
- W1974507908 cites W2108649886 @default.
- W1974507908 cites W2110649177 @default.
- W1974507908 cites W2110728570 @default.
- W1974507908 cites W2112369131 @default.
- W1974507908 cites W2123000765 @default.
- W1974507908 cites W2124733101 @default.
- W1974507908 cites W2124813164 @default.
- W1974507908 cites W2133019124 @default.
- W1974507908 cites W2154755614 @default.
- W1974507908 cites W2157860584 @default.
- W1974507908 cites W2160277958 @default.
- W1974507908 cites W2162815565 @default.
- W1974507908 cites W2164187120 @default.
- W1974507908 cites W2168801997 @default.
- W1974507908 cites W4361960923 @default.
- W1974507908 doi "https://doi.org/10.1016/j.celrep.2013.12.006" @default.
- W1974507908 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3932704" @default.
- W1974507908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24373286" @default.
- W1974507908 hasPublicationYear "2013" @default.
- W1974507908 type Work @default.
- W1974507908 sameAs 1974507908 @default.
- W1974507908 citedByCount "65" @default.
- W1974507908 countsByYear W19745079082013 @default.
- W1974507908 countsByYear W19745079082014 @default.
- W1974507908 countsByYear W19745079082015 @default.
- W1974507908 countsByYear W19745079082016 @default.
- W1974507908 countsByYear W19745079082017 @default.
- W1974507908 countsByYear W19745079082018 @default.
- W1974507908 countsByYear W19745079082019 @default.
- W1974507908 countsByYear W19745079082020 @default.
- W1974507908 countsByYear W19745079082021 @default.
- W1974507908 countsByYear W19745079082022 @default.
- W1974507908 countsByYear W19745079082023 @default.
- W1974507908 crossrefType "journal-article" @default.
- W1974507908 hasAuthorship W1974507908A5001446897 @default.
- W1974507908 hasAuthorship W1974507908A5006901857 @default.
- W1974507908 hasAuthorship W1974507908A5015618876 @default.
- W1974507908 hasAuthorship W1974507908A5017103335 @default.
- W1974507908 hasAuthorship W1974507908A5022413187 @default.
- W1974507908 hasAuthorship W1974507908A5024446376 @default.
- W1974507908 hasAuthorship W1974507908A5025901197 @default.
- W1974507908 hasAuthorship W1974507908A5026286078 @default.
- W1974507908 hasAuthorship W1974507908A5026921778 @default.
- W1974507908 hasAuthorship W1974507908A5028697711 @default.
- W1974507908 hasAuthorship W1974507908A5038280856 @default.