Matches in SemOpenAlex for { <https://semopenalex.org/work/W1974508736> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W1974508736 abstract "The possibility of modifying apoptosis-related genes in tumor cells is an interesting line of research that calls for multidisciplinary experimentation to describe its characteristics and the conditions required. In vitro low doses of alpha particle irradiation due to radon have an antiproliferative effect on the growth of MCF-7 cells and increase the sensibility of cancer cells to taxol, a chemotherapeutic agent that induces cellular apoptosis. The present study examines the in vitro effects of low doses of alpha particle irradiation from the gas radon on the expression of some bcl-2 family apoptosis-related genes. The analyzed genes were bax, bcl-2 and bcl-x, with known responses to genotoxic stress (bcl-2) or ionising radiation (bax and bcl-x) in MCF-7 human breast cancer cells. The results obtained indicate that the cell line studied expresses the mentioned genes and they demonstrate that irradiation with low radon doses of MCF-7 cells induces underexpression of both bax and bcl-2 genes. Interestingly, the mRNA levels of the full-length bcl-x gene (bcl-xL) were overexpressed after irradiation, and we found significant mRNA levels of an alternative mRNA splicing form of the same gene (bcl-xS), which enhances the apoptotic sensitivity of the cell. The increased sensitivity to apoptosis resulting from bcl-xS overexpression is important because it might improve the efficacy of chemotherapeutic agents used to treat cancers which act through induction of apoptosis. The finding that low radiation doses of alpha particles from the gas radon modulate the expression of apoptosis-related genes suggests a therapeutic utility for this naturally occurring agent." @default.
- W1974508736 created "2016-06-24" @default.
- W1974508736 creator A5032923173 @default.
- W1974508736 creator A5071391216 @default.
- W1974508736 creator A5079686516 @default.
- W1974508736 creator A5086132081 @default.
- W1974508736 date "2006-03-01" @default.
- W1974508736 modified "2023-10-01" @default.
- W1974508736 title "Low doses of alpha particle irradiation modify the expression of genes regulating apoptosis in human MCF-7 breast cancer cells" @default.
- W1974508736 cites W161930446 @default.
- W1974508736 cites W1965620353 @default.
- W1974508736 cites W1975579173 @default.
- W1974508736 cites W2016529779 @default.
- W1974508736 cites W2027265085 @default.
- W1974508736 cites W2037621441 @default.
- W1974508736 cites W2037932319 @default.
- W1974508736 cites W2049524934 @default.
- W1974508736 cites W2051934250 @default.
- W1974508736 cites W2061164281 @default.
- W1974508736 cites W2062043569 @default.
- W1974508736 cites W2063176993 @default.
- W1974508736 cites W2065167701 @default.
- W1974508736 cites W2067691101 @default.
- W1974508736 cites W2089773893 @default.
- W1974508736 cites W2111209219 @default.
- W1974508736 cites W2128848742 @default.
- W1974508736 cites W2134812217 @default.
- W1974508736 cites W2134979684 @default.
- W1974508736 cites W2151854064 @default.
- W1974508736 cites W2161945922 @default.
- W1974508736 cites W2278556698 @default.
- W1974508736 cites W2426475784 @default.
- W1974508736 cites W2571036723 @default.
- W1974508736 cites W26755955 @default.
- W1974508736 doi "https://doi.org/10.3892/or.15.3.577" @default.
- W1974508736 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16465415" @default.
- W1974508736 hasPublicationYear "2006" @default.
- W1974508736 type Work @default.
- W1974508736 sameAs 1974508736 @default.
- W1974508736 citedByCount "1" @default.
- W1974508736 countsByYear W19745087362020 @default.
- W1974508736 crossrefType "journal-article" @default.
- W1974508736 hasAuthorship W1974508736A5032923173 @default.
- W1974508736 hasAuthorship W1974508736A5071391216 @default.
- W1974508736 hasAuthorship W1974508736A5079686516 @default.
- W1974508736 hasAuthorship W1974508736A5086132081 @default.
- W1974508736 hasBestOaLocation W19745087361 @default.
- W1974508736 hasConcept C109541995 @default.
- W1974508736 hasConcept C111337013 @default.
- W1974508736 hasConcept C121332964 @default.
- W1974508736 hasConcept C121608353 @default.
- W1974508736 hasConcept C153911025 @default.
- W1974508736 hasConcept C18231593 @default.
- W1974508736 hasConcept C185544564 @default.
- W1974508736 hasConcept C190283241 @default.
- W1974508736 hasConcept C2781018059 @default.
- W1974508736 hasConcept C29537977 @default.
- W1974508736 hasConcept C2994423619 @default.
- W1974508736 hasConcept C502942594 @default.
- W1974508736 hasConcept C54355233 @default.
- W1974508736 hasConcept C81885089 @default.
- W1974508736 hasConcept C86803240 @default.
- W1974508736 hasConcept C96232424 @default.
- W1974508736 hasConceptScore W1974508736C109541995 @default.
- W1974508736 hasConceptScore W1974508736C111337013 @default.
- W1974508736 hasConceptScore W1974508736C121332964 @default.
- W1974508736 hasConceptScore W1974508736C121608353 @default.
- W1974508736 hasConceptScore W1974508736C153911025 @default.
- W1974508736 hasConceptScore W1974508736C18231593 @default.
- W1974508736 hasConceptScore W1974508736C185544564 @default.
- W1974508736 hasConceptScore W1974508736C190283241 @default.
- W1974508736 hasConceptScore W1974508736C2781018059 @default.
- W1974508736 hasConceptScore W1974508736C29537977 @default.
- W1974508736 hasConceptScore W1974508736C2994423619 @default.
- W1974508736 hasConceptScore W1974508736C502942594 @default.
- W1974508736 hasConceptScore W1974508736C54355233 @default.
- W1974508736 hasConceptScore W1974508736C81885089 @default.
- W1974508736 hasConceptScore W1974508736C86803240 @default.
- W1974508736 hasConceptScore W1974508736C96232424 @default.
- W1974508736 hasLocation W19745087361 @default.
- W1974508736 hasLocation W19745087362 @default.
- W1974508736 hasOpenAccess W1974508736 @default.
- W1974508736 hasPrimaryLocation W19745087361 @default.
- W1974508736 hasRelatedWork W1973455274 @default.
- W1974508736 hasRelatedWork W1997976267 @default.
- W1974508736 hasRelatedWork W2023499824 @default.
- W1974508736 hasRelatedWork W2035307859 @default.
- W1974508736 hasRelatedWork W2122407633 @default.
- W1974508736 hasRelatedWork W2347282438 @default.
- W1974508736 hasRelatedWork W2381753167 @default.
- W1974508736 hasRelatedWork W2513729362 @default.
- W1974508736 hasRelatedWork W3030161615 @default.
- W1974508736 hasRelatedWork W3141756411 @default.
- W1974508736 isParatext "false" @default.
- W1974508736 isRetracted "false" @default.
- W1974508736 magId "1974508736" @default.
- W1974508736 workType "article" @default.