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- W1974513387 abstract "Following transection of the optic nerve, ganglion cells in the cat retina undergo retrograde degeneration. However, many small profiles (≤ 10 μm) survive in the ganglion cell layer. Previously considered to be neuroglia, there is now substantial evidence that they are displaced amacrine cells. Their density increases from approximately 1,000 cells/mm2 in peripheral retina to 7,000 cells/mm2 in the central area. Their total number was found to be 850,000, which is five times the number of ganglion cells and also five times the number of astrocytes. Uptake of 3H-muscimol followed by autoradiography labelled 75% of the displaced amacrine cells; hence, the majority seem to be GABAergic. Immunocytochemistry with an antibody directed against choline-acetyltransferase labelled approximately 10% of the displaced amacrines in the peripheral retina and 17% in the central area. Uptake of serotonin (5–HT) followed by immunocytochemistry was found in 25–30% of displaced amacrines. NADPH diaphorase histochemistry labelled approximately 5% of displaced amacrine cells. The sum of the various percentages makes colocalization likely. Intracellular injection of Lucifer Yellow under microscopic control revealed that displaced amacrine cells constitute several morphological types." @default.
- W1974513387 created "2016-06-24" @default.
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- W1974513387 date "1987-11-15" @default.
- W1974513387 modified "2023-10-16" @default.
- W1974513387 title "Amacrine cells in the ganglion cell layer of the cat retina" @default.
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- W1974513387 doi "https://doi.org/10.1002/cne.902650308" @default.
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