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- W1974518982 abstract "Collaborative Group of the Primary Prevention Project (PPP). Low-dose aspirin and vitamin E in people at cardiovascular risk: a randomised trial in general practice. Lancet2001 Jan 13; 357 : 89 –95 [OpenUrl][1][CrossRef][2][PubMed][3][Web of Science][4] QUESTION: In patients with ≥1 cardiovascular risk factor but no history of cardiovascular disease, do aspirin and vitamin E prevent cardiovascular events? Randomised (allocation concealed), unblinded, 2 × 2 factorial trial with a mean follow up of 3.6 years. 315 general practices and 15 hospital hypertension units in Italy. 4495 patients (mean age 64 y, 58% women) aged ≥50 years who had ≥1 major cardiovascular risk factor: age ≥65 years, hypertension, hypercholesterolaemia, diabetes mellitus, obesity, and family history of myocardial infarction (MI) before 55 years of age in ≥1 parent or sibling. Exclusion criteria were treatment with antiplatelet drugs, chronic use of anti-inflammatory agents or anticoagulants, contraindication … [1]: {openurl}?query=rft.jtitle%253DLancet%26rft.stitle%253DLancet%26rft.aulast%253Dde%2BGaetano%26rft.auinit1%253DG.%26rft.volume%253D357%26rft.issue%253D9250%26rft.spage%253D89%26rft.epage%253D95%26rft.atitle%253DLow-dose%2Baspirin%2Band%2Bvitamin%2BE%2Bin%2Bpeople%2Bat%2Bcardiovascular%2Brisk%253A%2Ba%2Brandomised%2Btrial%2Bin%2Bgeneral%2Bpractice.%2BCollaborative%2BGroup%2Bof%2Bthe%2BPrimary%2BPrevention%2BProject.%26rft_id%253Dinfo%253Adoi%252F10.1016%252FS0140-6736%252800%252903539-X%26rft_id%253Dinfo%253Apmid%252F11197445%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/external-ref?access_num=10.1016/S0140-6736(00)03539-X&link_type=DOI [3]: /lookup/external-ref?access_num=11197445&link_type=MED&atom=%2Febnurs%2F4%2F3%2F86.atom [4]: /lookup/external-ref?access_num=000166476200009&link_type=ISI" @default.
- W1974518982 created "2016-06-24" @default.
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- W1974518982 date "2001-07-01" @default.
- W1974518982 modified "2023-09-26" @default.
- W1974518982 title "Aspirin but not vitamin E prevented cardiovascular events in patients at risk" @default.
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- W1974518982 doi "https://doi.org/10.1136/ebn.4.3.86" @default.
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