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- W1974520072 abstract "Hematopoietic stem cells (HSCs) are capable of self-renewal and differentiation into all blood cell types. During adult life, they reside in the bone marrow in a quiescent state. By contrast, in the growing embryo hematopoiesis is sequentially found in several developmental niches. This review provides an overview of the still controversial contribution of each of these embryonic sites to the final pool of adult HSCs and discusses new insights into the cellular origin and the molecular regulation implicated in the generation of blood progenitor cells. A better understanding of HSC development during ontogeny is essential to develop new strategies to amplify HSCs or to generate them from embryonic stem cells or by somatic cell reprogramming. Hematopoietic stem cells (HSCs) are capable of self-renewal and differentiation into all blood cell types. During adult life, they reside in the bone marrow in a quiescent state. By contrast, in the growing embryo hematopoiesis is sequentially found in several developmental niches. This review provides an overview of the still controversial contribution of each of these embryonic sites to the final pool of adult HSCs and discusses new insights into the cellular origin and the molecular regulation implicated in the generation of blood progenitor cells. A better understanding of HSC development during ontogeny is essential to develop new strategies to amplify HSCs or to generate them from embryonic stem cells or by somatic cell reprogramming." @default.
- W1974520072 created "2016-06-24" @default.
- W1974520072 creator A5013394786 @default.
- W1974520072 creator A5022535195 @default.
- W1974520072 creator A5054219907 @default.
- W1974520072 date "2012-05-01" @default.
- W1974520072 modified "2023-10-16" @default.
- W1974520072 title "Origin of blood cells and HSC production in the embryo" @default.
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- W1974520072 doi "https://doi.org/10.1016/j.it.2012.01.012" @default.